-Caveat Lector-

'Machine' Crafted Out of DNA

By RICK CALLAHAN Associated Press Writer

Scientists have made a moving part out of a few strands of DNA, a step toward
building incredibly tiny "machines" that could someday perform intricate jobs
like building computer circuits and clearing clogged blood vessels in the
brain.

The hinge-like part, which bends on cue, is just four-ten-thousandths of the
width of a human hair.

The new work isn't the first time scientists have turned chemical compounds
into moving parts. But previous examples have been hampered by their floppy
nature. The DNA device, however, is particularly rigid and executes motions 10
times bigger, lead researcher Nadrian C. Seeman said.

The device was made by joining two double-stranded DNA spirals with a bridge
of DNA. When it's exposed to a particular chemical solution, part of the
structure bends.

The findings were reported in Thursday's issue of the journal Nature by Seeman
and colleagues at New York University. The team hopes to eventually build
other moving parts using DNA, including "arms" and "fingers" that someday
could be mounted on a micro-robot.

The work is the latest twist in the fledgling field of nanotechnology, or
technology at an atomic scale.

"This is a very beautiful demonstration of construction at that scale of a
device that's actually functioning," said Daniel T. Colbert of Rice
University's Center for Nanoscale Science and Technology.

However, Colbert said scientists are still decades away from creating any
useful machines in nanotechnology.

"We're kind of in the children's playtime toddler era of doing this. We've
been thrown some blocks and Legos and Tinker Toys," he said. "We're just kind
of picking them up and trying to assemble things out of them that can perform
something useful."

K. Eric Drexler of the Institute for Molecular Manufacturing in Los Altos,
Calif., agreed that Seeman's device is too cumbersome to be useful. But he
said further development may lead to a practical device.

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