-Caveat Lector-

GM food harmed rats, says research
http://www.independent.co.uk/
13 February 1999

By Steve Connor, Science Editor

A group of scientists warned of serious health dangers from eating
genetically modified (GM) food yesterday, citing unpublished research
allegedly showing that GM potatoes have damaged laboratory rats.

The independent scientists vigorously defended the work of Arpad Pusztai, an
expert on plant toxins, who was forced to retire last year from his post at
the Rowett Research Institute in Aberdeen after prematurely releasing the
results of his experiments to the World in Action television programme .

Twenty researchers from around the world have signed a memorandum condemning
the way Dr Pusztai was treated by the Rowett Institute, which said the
68-year-old scientist had become "muddled" over an experiment that did not
in fact involve genetically modified potatoes.

Dr Pusztai was suspended and his annual contract not renewed. He has since
been told not to talk publicly about his work on GM potatoes by his former
employer.

But yesterday Vyvyan Howard, a toxicologist from Liverpool University,
released data from further experiments carried out by Dr Pusztai which, said
Dr Howard, supports the principal conclusion that genetically modified food
can be harmful to health.

Dr Howard said that "transgenic" potatoes, which had an added gene
responsible for a plant toxin called a lectin, produced damaging effects on
the immune systems and internal organs of the laboratory animals. "There is
obviously something going on with this transgenic potato which is not just
due to the lectins. We don't have an answer to that. It needs further
research," he said.

Stanley Ewen, of the department of pathology at Aberdeen University,
released preliminary results of his own experiments, which showed that
animals fed on GM potatoes experienced the take-up of lectin proteins into
the cells of their intestines. "It may be that in GM food a drug-delivery
system has been created, delivering something you didn't want to," Dr Ewen
said.

Another supporter of Dr Pusztai, Professor Brian Goodwin, of Schumacher
College in Dartington, Devon, said the latest results will strengthen
support for an immediate moratorium on the growth of GM crops, a ban on
patenting genes and an independent inquiry into the use of genetic
engineering by the food and agricultural industries.

Ronald Finn, past president of the British Society of Allergy and
Environmental Medicine, said Dr Pusztai's research raised serious concerns.
"Dr Pusztai's results to date at the very least raise the suspicion that
genetically modified potatoes may damage the immune system." If that
happened, he said, the consequences of something like a flu epidemiccould be
extremely serious. "You can imagine a doomsday scenario. If the immune
system of the population was weakened, then the mortality would be increased
many, many times."

Other scientists criticised Dr Pusztai's supporters for taking his research
out of context. Professor Ray Baker, chief executive of the Biotechnology
and Biological Research Council, said the potato experiments did not cast
doubt on the safety of all GM food. "These potatoes were part of an
experiment and were never intended for commercial production, nor are they
available on the market," he said.

As the row over Dr Pusztai erupted, Tony Blair yesterday rejected calls for
a moratorium on GM food and played down mounting concern. "There is no GM
food that can be sold in this country without going through a very long
regulatory process," he said on BBC radio. "Let's proceed on the basis of
genuine scientific analysis and inquiry, proceed with very great care and
caution and not get the facts mixed up."

Philip James, director of the Rowett Institute, vigorously defended his
decision to suspend Dr Pusztai on the grounds that the lectin expert had
become confused over key experiments on GM potatoes.

Dr James said that Dr Pusztai had claimed in media interviews to have found
ill-effects on rats fed with GM potatoes with a lectin called GNA - a
protein derived from the snowdrop plant - but in fact he had mistaken these
results for those on ordinary potatoes that had been deliberately laced with
high concentrations of another, highly toxic lectin called Con A, which
would never be used in human food.

Dr James strongly denied that he had come under any political pressure to
dismiss Dr Pusztai.

The environmental pressure group Friends of the Earth called on the Prime
Minister yesterday to hold an inquiry into the affair.

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