-Caveat Lector-

University Ends Psychosis Study

CINCINNATI (AP) -- The University of Cincinnati has dropped psychiatric
studies in which patients were given a chemical that may cause psychosis.

The announcement Wednesday comes as federal investigators are examining
research practices at the university and Cincinnati's Veterans Administration
Medical Center, which are affiliated.

The university's study that raised concern was a 1997 clinical trial in which
13 patients who were delusional or hallucinating were asked to take
amphetamines, which can make the symptoms worse. Giving people chemicals that
may induce psychosis -- a severe form of mental illness -- was intended to
help researchers learn how psychosis happens, or to test a treatment.

Critics complained that people with psychoses severe enough to be
hospitalized were denied treatment for their illnesses for five days just to
complete the study.

Dr. Randy Hillard, head of the university's department of psychiatry, said
the amphetamine study was conducted with adequate safety measures. But he
said that no more of those studies will be done by his department until
critics are satisfied.

``Nationwide, there is enough of a question ... that we will stop doing them
until there is a consensus about how they should be done,'' Hillard said.

He commented after meeting Wednesday with four Cincinnati-area advocates for
the mentally ill.

In November, a presidential advisory commission recommended increased
protections for people with mental disorders involved in research, including
giving family and friends more say in what happens. The National Bioethics
Advisory Commission proposed new federal guidelines to try to ensure that
people with disorders such as dementia, schizophrenia and delirium are not
exploited.

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