-Caveat Lector-

Wistar Responds to Claims on AIDS Origin
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By David Morgan

PHILADELPHIA, Nov 10 (Reuters) - An eminent US medical research center will
release lab specimens from a 1950s polio vaccine project in Africa in hopes
of dispelling claims that its scientists inadvertently caused the AIDS
epidemic, officials said on Monday.

For more than a decade, the Wistar Institute and two of its leading
scientists have been dogged by speculation that the AIDS virus was
transmitted from chimpanzees to humans through an oral polio vaccine given to
more than 1 million people, mostly children, in central Africa.

Officials at the private, nonprofit institute said it would allow two
independent labs to test material from the 1957-1960 vaccine trials in hopes
that this will end the controversy by showing no evidence of simian
immunodeficiency virus (SIV), which affects chimpanzees.

Scientists believe the AIDS epidemic, which has stricken 33 million people
worldwide, began after SIV was transmitted from chimpanzees to human beings
in western central Africa. Officials at the US Centers for Disease Control
say it probably occurred during the slaughter of chimpanzees as early as the
1930s.

Recently, however, the polio vaccine theory has been thrown back into the
spotlight by a new book by British journalist Edward Hooper, whose research
suggests that vaccine batches may been made from chimpanzee kidneys and
tainted with SIV.

Two Wistar scientists who led the polio research, former institute director
Dr. Hilary Koprowski and his former deputy Dr. Stanley Plotkin, reject this
suggestion.

"The idea is a house of cards built on circumstantial evidence, and whatever
doesn't fit has been ignored. It's also, frankly, an attack on people's
reputations, and I feel it has to be dealt with," said Dr. Plotkin, 67, who
developed the modern rubella vaccine before leaving Wistar for France's
Pasteur Merrieux Connaught.

Two laboratories, which will be selected by Dr. Plotkin, will conduct the
tests and will have the specimens by the end of this year.

"We just feel we can put that issue to rest if it's tested. Then...we've done
exactly what people feel would be necessary at least to relieve the tension
over this issue," Wistar Chief Administrator Clayton Buck said.

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