-Caveat Lector-

http://www.washingtonpost.com/wp-dyn/health/A2144-1999Dec16.html


 Signature Found for Attention-Deficit

 Associated Press
 Friday, December 17, 1999; Page A28

 Brain scans have revealed measurable biochemical
 differences in people with attention-deficit/hyperactivity
 disorder (ADHD), a discovery that could reduce the number
 of children mistakenly diagnosed and put on drug treatment,
 researchers say.

 The diagnosis of ADHD, usually made in school-age children,
 is commonly based on observed behavior and some experts
 believe it is highly subjective. Some say the condition is
 being overdiagnosed in the United States, exposing children
 unnecessarily to medication; others argue it is not treated
 often enough.

 Earlier studies have shown scans can detect structural
 differences in ADHD sufferers' brains, as well as
 abnormalities in brain activity, and scientists suspect
 that defects in genes relating to the brain chemical
 dopamine probably are involved.

 The latest study, conducted at Massachusetts General
 Hospital in Boston and published in this week's issue of
 the Lancet medical journal, is the first to show a
 measurable biochemical abnormality in people with the
 disorder.

 Dopamine is associated with movement, thought, motivation
 and pleasure. One brain cell signals another by squirting
 dopamine. Then the first cell mops up the released chemical
 with a structure called a dopamine transporter.

 The researchers scanned the brains of six adults diagnosed
 with ADHD and 30 healthy people of the same age after
 injecting both groups with a chemical agent that attaches
 to the dopamine transporter.

 The ADHD sufferers had 70 percent more dopamine
 transporters than their healthy counterparts.

 The scientists could not tell, however, whether that was a
 cause or an effect of the disorder.



 � 1999 The Washington Post Company




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