Date: 1 Aug 2000 16:08:01 -0400
From: Joseph R Parrish Jr <[EMAIL PROTECTED]>
Source: The Star-Ledger, 1 Aug 2000, [edited]


West Nile virus spreads into Union County
- -----------------------------------------
West Nile virus has been blamed for the deaths of 6 more crows, bringing to
15 the number of birds in 4 New Jersey counties found stricken with the
disease, officials said yesterday. For the first time, Union County joined
the list of West Nile virus hot spots as officials confirmed two crows
found in Elizabeth and Rahway were among the latest to produce positive
blood samples in a state laboratory. 3 of the crows were found in Bergen
County, the fourth in Sayreville in Middlesex County.

"I'm not surprised. We don't live in a bubble. They have been finding them
all around us," said Carolyn Vollero, the chief inspector for Union County
Mosquito Control. She noted the proximity of Elizabeth to Staten Island,
where dead crows have also tested positive. Vollero said the county would
continue it's ground spraying and other mosquito-control efforts, but
insisted there would be no conversion to the kind of aerial spraying taking
place in residential neighborhoods of New York City. "We don't need to
press the panic button," she said.

The 3 new Bergen County sites where crows tested positive were Bergenfield,
Hasbrouck Heights and Old Tappan. 10 of the 15 birds shown to be infected
have been recovered in Bergen, officials say. One bird collected in Hudson
County tested positive last month. "It's only a matter of time before we're
testing positive across the board in Bergen County," said Rod Preiss, the
health officer for the Northwest Bergen Regional Health Commission. The
commission covers 7 towns, including Old Tappan and Montvale, where a dead
crow previously tested positive.

More than two dozen people have been tested for suspected West Nile virus
infections. Not one has tested positive, state officials say. There have
also been no reports in New Jersey of infected mosquitoes.

(Byline Angela Stewart <[EMAIL PROTECTED]>)

- --
Joseph R Parrish Jr
<[EMAIL PROTECTED]>

[This and similar information can now be put into context by referring to
the CDC interactive maps which are now coming on-line. These maps will be
up-dated weekly and provide a visual record of the progress of the West
Nile virus epizootic. See "West Nile virus surveillance: interactive maps
2000.3055". -Mod.CP]
...............................cp/ds

==========================

Date: 2 Aug 2000 8:56:30 -0400
From: Randall L Crom <[EMAIL PROTECTED]>


[The following comments have been received from Dr. Randall L. Crom (USDA,
APHIS, Veterinary Services, 4700 River Road, Unit 41, Riverdale, MD
20737-1231) in response to issues raised by Dr. Kellon. The posting has
been delayed by misdirection of mail. -Mod.CP]

This is to provide some information on the West Nile virus (WNV) related
issues raised on ProMED-mail recently [West Nile virus, crow - USA (New
York) (04)]. The total number of birds positive this year for WNV is
available, by county, for 19 state and local jurisdictions currently
participating in the National West Nile Virus Surveillance System. Maps of
positive findings can be found on the World Wide Web at:
<http://nationalatlas.gov/virusmap.html>

As for the movement of horses from areas with known WNV infections in
equine, here is some background information. The Animal and Plant Health
Inspection Service (APHIS) of USDA is responsible for oversight of
interstate and international movements of livestock, including horses. A
health certificate is required for any interstate or international
movement. Such a certificate would not be issued to a horse showing signs
of illness. Thus, horses with clinical WNV infection would not be allowed
to move interstate nor internationally. The decision not to impose
restrictions on the movement of horses that are not clinically ill was
based on an extensive review of the scientific literature on horses and
WNV. Your statement that "horses (and lemurs)... may play a significant
role in the epidemiology of West Nile virus infection" appears to be based
on a statement in a paper by Hub�lek et al. published in the journal
"Emerging Infectious Diseases" in 1999. In that paper there is one
reference given for a similar statement on horses and lemurs. However, the
cited reference gives information only about lemurs, not about horses. Upon
our further inquiry, the author cited a reference text (Hannoun et al.,
1969) that states that one experimentally inoculated one-year old foal
developed sometimes high levels of circulating virus." The same text says
that an inoculated adult horse developed a "low viremia." No quantitative
details about the results or methods of the experiment were given.

All other evidence of which we are aware, including other peer-reviewed
papers (e.g., Schmidt et al., 1963) and reference texts (e.g., Anonymous,
1987; Hayes, 1989; Peiris et al., 1994), indicates that horses develop
relatively low viremias. Further, there is no epidemiological nor empirical
evidence of horses ever having been involved in the origin or propagation
of an epizootic of WNV. Based on this evidence it was concluded that horses
do not play a significant role in the epidemiology of WNV but at the most
are only incidental (dead-end) hosts. Further evidence that horses develop
relatively low viremias can be found in the results of yet unpublished WNV
studies, including an equine inoculation study conducted by USDA-APHIS in
late 1999. That study found a maximum WNV viremia in horses of 2.5 log 10
per ml of plasma. Such a viremia is considered to be below the level at
which a mosquito could acquire WNV from a horse. Further equine inoculation
and transmission studies are underway at Colorado State University (CSU),
primarily in collaboration with the Centers for Disease Control and
Prevention (CDC). Preliminary results of the first phase of that study are
consistent with the USDA study in terms of maximum viremias observed. In
the second phase of the CSU/CDC studies, virgin mosquitoes are being fed on
WNV-infected horses to see if they can become infected. Unless credible
evidence of transmission, or of a significant potential for transmission,
of WNV from horses to mosquitoes is found, restrictions on movements of
horses from WNV-affected areas will not be imposed by USDA-APHIS. Currently
there is no such evidence. There are also no areas in the United States in
which equine are currently known to be infected with WNV.

Publications with information on WNV in horses:

Anonymous. 1987. West Nile fever. In: Zoonoses and communicable diseases
common to man and animals, 2nd ed. (Acha, P.N., Szyfres, B., Eds.). Pan
American Health Organization (Scientific publication no. 503), Washington,
D.C. 525-528.

Cantile, C., Di Guardo, G., Eleni, C., Arispici, M. 2000. Clinical and
neuropathological features of West Nile virus equine encephalomyelitis in
Italy. Equine Vet J 32(1):31-35.

Hannoun, C., Panthier, R., Corniou, B. 1969. Epidemiology of West Nile
infections in the south of France. In: Arboviruses of the California
Complex and Bunyamwera Group (B�rdos, V., Ed.). Vydav. SAV, Bratislava.
379-387.

Hayes, C.G. 1989. West Nile fever. In: The arboviruses: epidemiology and
ecology, Vol. V (Monath, T., Ed.). CRC Press, Boca Raton, FL. 59-88.

Hub�lek, Z., Halouzka, J. 1999. West Nile fever - a reemerging
mosquito-borne viral disease in Europe. Emerg Infect Dis 5(5):643-650.
<http://www.cdc.gov/ncidod/eid/vol5no5/hubalek.htm>

Peiris, J.S.M., Amerasinghe, F.P. 1994. West Nile fever. In: Handbook of
zoonoses, section B: viral, 2nd Ed. (Beran, G., Ed.). CRC Press, Boca
Raton, FL. 139-148.

Schmidt, J.R., El Mansoury, H.K. 1963. Natural and experimental infection
of Egyptian equines with West Nile virus. Ann Trop Med Parasitol 57:415-427.

- --
Dr. Randall L. Crom
USDA, APHIS, Veterinary Services
4700 River Road, Unit 41
Riverdale, MD 20737-1231
Tel.: (301) 734-8423
Fax: (301) 734-7817
<[EMAIL PROTECTED]>
<http://www.aphis.usda.gov>
...................................................cp/ds

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