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http://www.konformist.com/2000/drugwar/drugfungus-hogshire.htm
http://www.konformist.com/2000/drugwar/drugfungus.htm


Spring 1998
Covert Action Quarterly
Contact: [EMAIL PROTECTED]
Website: http://www.caq.com

THE DRUG WAR'S FUNGAL SOLUTION?
Jim Hogshire

The USDA has been tinkering with the genetic code of a dangerous fungus
trying to target and wipe out the Andean coca and poppy crops. But if
anything goes wrong, the fusarium fungus may end up destroying food crops
and a whole lot more.

This past August, a piece of good news came from the maze of nameless
buildings at the USDA's Agricultural Research Service (ARS) in Beltsville,
Maryland. Dr. Deborah R. Fravel, a plant pathologist at the laboratory for
Biocontrol of Plant Diseases (BCPD) had turned the tables on a nasty,
tomato-eating fungus called Fusarium oxysporum. She had developed a "benign"
strain of the fungus that "inoculates" the tomatoes, much as a vaccine
protects a child against certain diseases.

And the fungus is nasty. A virulent mutation of fusarium, called "Race 3"
has been a bane to Florida and Georgia farmers who have trouble controlling
it with even the strongest fungicides. Around the world, fusarium also
destroys watermelons, chickpeas, basil, bananas, and hundreds of other
crops. The blight, in all its myriad permutations, can lie dormant in the
soil for years without a host plant and then springs to life, causing
devastating "wilt disease." Fear of introducing the disease is one reason
Japan is loath to accept US produce. While some strains of this fungus are
relatively harmless to most plants, other types of fusarium can produce
mycotoxins poisonous to humans.

The Fungus Among Us

But the USDA press release was warm and fuzzy describing "good" fungi
"helping plants to help themselves."

There was no mention of Fravel's part in dozens of projects aimed at
producing a lethal, but "natural" herbicide from the same fungus for a very
different purpose. Fravel's efforts are part of a cabal of scientists
working hand in hand with the DEA, the State Department, and foreign
governments to produce an herbicide designed to effect the drug war's Final
Solution: total elimination of the world's illicit coca crops and opium
poppies - the same goal recently announced by the United Nations.

Fravel's boss at the BCPD, Dr. Robert D. Lumsden, is a prominent figure in
the eradication research program. Lumsden's work with mutant strains of
Fusaruim oxysporum over the past few years has taken him to sites around the
world and across the country. At the University of Montana in Bozeman, he
and another ARS plant pathologist, Dr. Bryan A. Bailey, are in the midst of
a five-year study of the toxic effects of F. oxysporum and other fungi on
opium poppies and marijuana. According to one of Lumsden's reports, unlike

chemical herbicides, "these naturally-occurring fungi are safe for humans
and the environment."

Lumsden worked with Bailey to develop a granular formulation fusarium
mycotoxin, for testing at sites "foreign and domestic." A government coca
field in Hawaii was eventually used to test the mycotoxin, along with
traditional chemical herbicides. A 1995 study of fusarium herbicide showed
"significant kill" of coca bushes while other studies indicate a 60 to 90
percent kill-rate for opium poppies. When scientists no-ticed that ants
sometimes carried away the poison pellets, Fravel and Bailey looked for ways
to make them more attractive to the insects - so they would take the
herbicide deeper into the soil. The ants (which preferred their pellets
flavored with olive oil) were found to carry the fungus both "outside and
inside their bodies."

Changing Genes

Later research by Bailey and others identified the gene responsible for one
strain's deadly effects on coca. They then developed a way "to allow
alteration of the gene expression." They began to play with the fungus'
genetic code.

The ARS's long-standing interest in manipulating the fusarium fungus is
revealed in a series of studies it commissioned. One experiment set out "to
construct a genetic map of Fusarium moniliforme" and "to identify mutants
that affect the synthesis of" its mycotoxins. Another study proposed "the
development of strains with enhanced pathogenicity" that could wipe out coca
plants "using molecular genetic manipulations involving fungal proteins."
The ARS branch in Ft. Detrick, Maryland, carried out the "successful
transformation of Fusarium oxysporum" by "DNA sequence encoding." Claiming
that it would have "limited environmental impact," another ARS study
acknowledged that a "biocontrol strategy for coca" using Fusarium oxssporum
had been "developed and successfully field tested in small scale trials."

Researchers hint that they took their cue for the mycotoxin from a naturally
occurring outbreak of fusarium wilt destroying crops in Peru's Upper
Huallaga valley. An ongoing ARS project, begun in 1993, noted:

"Studies of a naturally-occurring epidemic of fusarium wilt in Peru have
been concluded which verify that the epidemic is progressing and causing
significant disease in the coca producing regions of Peru. Already, the
natural epidemic of fusarium wilt in the coca producing areas of Peru is
causing farmers to abandon their fields. A protein produced by Fusarium
oxysporum which is toxic to E. coca has been purified and its gene cloned.
The data indicate that a bioherbicide using Fusarium oxysporum which is
effective against coca can be produced and proof of concept field tests are
being initiated."

As early as 1991, Peruvian campesinos testified that they witnessed
helicopters carrying DEA agents and Peruvian police dropping pellets
containing the fungus onto coca fields; however, there is no other solid
evidence to support the allegation that the pellets actually contained
fusariurn. Other press accounts allege a direct link between the DEA and the
use of fusarium:


"The US Drug Enforcement Administration resumed full cooperation with the
Peruvian police in 1994, when [the] strategy shifted to destroying illegal
coca plantations using a mushroom known scientifically as fusarium and
colloquially among the peasants as 'the coca-eater.'" Because there are so
many strains or races of fusarium, it may not be possible to determine if
this outbreak affecting coca and other crops is a result of natural causes
or human intervention.

Eat Stuff and Die

The problem with creating any "bug" that will eat just one thing and then
obediently cease to exist is obvious. All life-forms mutate and adapt,
especially a simple organism like a fungus; sooner or later it will learn to
eat something else. A similar situation occurred in 1971, when Richard Nixon
misinterpreted a theory about "an insect which could consume poppy crops"
and then die. Nixon, preoccupied by this imaginary weevil, by then dubbed
the "screw worm" (because it was supposed to die after intercourse), asked
Congress for funding. When Nixon's advisors could not be assured that this
"screw worm" would be host specific - i.e., it might eat the worid's supply
of poppy crops and then adapt to another host, such as rice or wheat - they
lost interest in the project. Eventually even these knuckleheads dropped the
idea.

But research into doper bugs continued. In 1996, Bailey, Lumsden, and Fravel
- working on a project at North Carolina State University in Raleigh - wrote
that their finely tuned pathogen "kills only coca and does not harm other
plants." A recently launched study, however, suggests that the fusarium
formulas are still not specific enough. One ARS investigator is studying the
"ubiquitous species-complex of Fusarium oxysponum [that] is currently being
investigated as a biological control agent. However, this fungus encompasses
broad genetic variability that has not yet been delineated." There is, the
researcher continues, "still a need to characterize genetically the strains
that attach Erthrroxylon [coca] and/or Papaver [poppies] as well as those
that occur in soils and on crop plants growing in close proximity."
Translation: the innumerable strains of the fungus could possibly attack
adjacent crops and do God-knows-what to everything else.

Perversely, the government touts the fungus project as environmentally
friendly because it avoids the use of chemicals. For years, the US has
browbeaten Andean pro-ducer countries into using US-produced herbicides such
as Roundup (glyphosate), and to kill off the "source" of the US drug
problem. The Andean nations have balked, arguing that US consumer demand
drives production, not the other way around. With the threat of withholding
millions in aid dollars to bolster its side, Washington has demanded
eradication. Local growers are then left not only without a cash crop, but
sick from the toxic effects of the herbicides.

Protests over the health effects of herbicides prompted Bolivia and Peru to
stand up to Washington and prohibit Roundup--like herbicides for coca and
poppy eradication. In early March 1996, Colombia abruptly halted herbicide

fumigation in retaliation for being "decertified" for not complying with US
drug war demands. Humans exposed to Monsanto Corporation's Roundup - the
current chemical of choice - can suffer damage to the stomach, heart,
kidneys, lungs and skin. Glyphosate, according to a 1993 study by the
University of California Berkeley School of Public Health, was the third
most commonly-reported cause of pesticide illness among agricultural
workers. Another study from the Berkeley school found that it was the most
frequently reported cause of pesticide illness among landscape maintenance
workers. As a drug eradication chemical, glyphosate has another problem: It
can be washed off for 8 hours after it is sprayed on, making it vulnerable
to rain - and farmers who rush into the freshly poisoned fields to wash the
toxins off their crops.

Armed with the more potent herbicide Spike (tebuthiuron), the US is now
pushing to use that defoliant in the drug war. Manufactured by Dow
AgroSciences (formerly DowElanco and then Eli Lilly before that merger), the
use of tebuthiuron has been hawked in Congress by Rep. Dan Bunon (R-IN) - a
longtime recipient of money from both Indianapolis based-Eli Lilly and Dow.

While killer fungi and many poisonous herbicides are not approved for use in
the US, people in developing countries often have no say in what toxins are
released in their communities. If some US officials have their way
unilateral decision-making could become the norm.

At a hearing he chaired on "certification" of nations in the drug war, Dan
Burton told the State Department's narcotics point man, Robert Gelbard, how
to handle countries that refused to be defoliated: "Tell the president [sic]
of Peru and Bolivia at about 5:00 in the morning, 'We've got a bunch of
aircraft carriers out here, and we're coming down through those valleys, and
we're gonna drop this stuff, this tebuthiuron...' I think we should
consider, if this really is a war on drugs, doing it unilaterally and
violating the territorial boundaries of those countries and dropping that
stuff. Now, I know that doesn't sit well with the State Department, but
either we deal with it or our kids continue to suffer and our society
continues to let this cancer grow."

Whether "our" kids should be "protected" by poisoning "their" kids, however,
is a policy issue that seems to escape US drug warriors. In their zeal to
sound ever tougher on drug issues, Washington policy makers - together with
fearless scientists eager to test their theories on other people's
communities - may soon have a new biological doomsday weapon to unleash on
their southern neighbors. At best, fusarium could become the latest bit of
humiliation unilaterally rammed down the throat of Andean nations. At worst,
the fungus could run amok unleashing the modern day equivalent of the Great
Potato Famine.


 May 2000

  ALARM OVER U.S. FUNGUS EXPERIMENTS ABROAD

  US experiments in Southern countries using microbial fungus to
  eradicate narcotic crops have raised great concern over the
  effects on human health, the environment and legitimate crops.
  This microbial fungus use is prohibited in the United States
  itself.

  By Chakravarthi Raghavan
  Third World Network Features

       Geneva: An international non-profit group has called on
  the Conference of Parties (COP) to the UN Convention on
  Biodiversity (CBD), meeting in Nairobi on 15-26 May, to act to
  halt experiments abroad by the United States to use 'Agent
  Green' microbes to kill narcotic crops.

       In a briefing paper for delegates to the 5th COP meeting,
  the 'Sunshine Project', a non-profit group based in Seattle
  and Hamburg, has complained that the US government was
  planning the testing and widespread application of microbial
  fungus to attack plants producing coca, opium poppy and
  cannabis (marijuana).

       This microbial fungus use, the group notes, is prohibited
  in the United States itself, while the UN General Assembly in
  1998 had specifically turned down proposals for the use of
  pathogens to kill narcotic crops.

       The microbial pathogens, the Sunshine Project says, pose
  risks to human health and to biodiversity, and their use is
  being promoted abroad - in Asia and the Amazon regions - by
  the United States as part of its war against narcotics. The
  pathogens have been tested only for their effectiveness
  against 'weeds', and not for safety for human health and the
  environment.

       The NGO group says that the US has begun conducting test
  programmes on fungi (Pleospora sp. and others) to kill opium
  poppy and marijuana. In the Andes and western Amazon, the US
  is planning testing and widespread application of a fungus
  that attacks coca - Fusarium oxysporum, f. sp. Exythoroxilum.

       These pathogens threaten human health and biodiversity in
  the Americas and Asia.

       The US Congress, the briefing document says, has recently
  appropriated $23 million for development of the pathogen
  agents and, in the Americas, is linking the fungal pathogen
  plan to the US aid programmes.

       These anti-crop fungus programmes have been labelled as
  'bio-control' research to eliminate weeds, the NGO says.

       'While plants producing narcotics are certainly
  undesirable, they are not "weeds" by any logical policy or
  regulatory definition. And "bio-control" is a misnomer for
  these pathogens. Legitimate bio-controls protect cultivated
  crops, but the US pathogens kill them.'

       And by appropriating the language of a legitimate branch
  of science, biological controls, the US programme has put the
  reputation of a growing and promising field of research at
  risk.

       The briefing document points out that in 1989, an expert
  group working on law enforcement and drug control issues for
  the UN Commission on Narcotic Drugs first suggested the use of
  biological agents to kill narcotic crops. Though nothing came
  of this, the US unilaterally pursued scientific development of
  the idea, with limited bilateral cooperation particularly from
  former Soviet research institutions in newly independent
  Central Asian states.

       In 1997, at US prodding, the Vienna-based UN Drug Control
  Programme (UNDCP) acted on the 1989 recommendation of experts
  and incorporated it into a global plan for eradication of
  illicit crops, SCOPE (Strategy for Coca and Opium Poppy
  Elimination).

       But the UN General Assembly in 1998 rejected the SCOPE
  move, and the idea of using narcotic crop pathogens was
  eliminated from the multilateral agenda. But the US, and some
  in the UNDCP, 'seem to have clung to the idea and are on the
  verge of implementing it', says the Sunshine Project.

       But since the US unilateral push for the use of these
  pathogens risks political exposure, the US Government has been
  pushing others to follow its lead. In a 1999 State Department
  cable (obtained under the Freedom of Information Act), the US
  Secretary of State has exhorted the UNDCP 'to find more
  support for fungal eradication, and to solicit funds from
  other governments, in order to avoid the perception that this
  is solely a US Government initiative'.

       But there has been little support from other countries,
  the Sunshine Project notes. While the UK provided some small
  supplemental funding for US-sponsored experiments with opium
  poppy fungus in Central Asia in the mid-1990s, no other donor
  country has responded to the US calls for support.

       The NGO briefing paper notes that with the exception of
  manual and mechanical plant removal, crop eradication
  programmes using chemical herbicides have been controversial.
  As early as 1988, the UN ECOSOC pointed out that drug
  eradication programmes should not use methods harming the
  environment or humans.

       Some countries like Bolivia, Peru and Thailand have laws
  or implemented policies banning chemical eradication because
  of the negative impacts of herbicides on the environment,
  human health and legitimate crops. Civil society opposition to
  such eradication has been intense.

       Applied in massive quantities from the air, such chemical
  herbicides as glyphosate (RoundUp), tebuthiuron (Spike) and
  hexaninone harm humans and biodiversity.

       But the US and the UNDCP maintain that herbicides used in
  specified ways are 'environmentally safe and non-toxic for
  humans'.

       But the US finds even these herbicides not strong enough,
  and is promoting fungal eradication to create plant sprays
  more lethal and long-lasting than glyphosate.

       Recently, Peru passed a law banning the use of biological
  agents in coca eradication. The UNDCP admitted in January this
  year that Kazakhstan and Turkmenistan have refused to carry
  out field-testing of opium poppy myoherbicide. And in a report
  for the Colombian Ombudsman for the Environment, leading
  Colombian scientists have said the use of such agents in
  Colombia represents 'a great danger both for humans as well as
  the Colombian environment and biodiversity'.

       The Sunshine Project notes that the use of fungal
  narcotic control has been halted in Florida, the world's top
  producer of cannabis.  A private company, Ag/Bio Con, which is
  connected to the United States Department of Agriculture,
  proposed using a cannabis-killing strain of Fusarium oxysporum
  in Florida.

       But the head of the Florida department of environment
  protection squashed the idea, saying this species was capable
  of evolving rapidly, and its mutagenicity is by far the most
  disturbing factor in its use as a bio-herbicide - it's
  impossible to control the spread of the Fusarium species.

       The mutated fungi, it was noted, could cause disease in a
  large number of crops - tomatoes, peppers, flowers, corn and
  vines - and is normally considered a threat to farmers as a
  pest, and not as a pesticide. The Fusarium species is more
  active in warm soils and can stay resident in the soil for
  years. This longevity and enhanced activity in Florida weather
  conditions could lead to an increased risk of mutagenicity.

       Despite this assessment, the Sunshine Project charges
  that the US is pressing the programme to the point when it is
  close to large releases. Field-tests are being conducted in
  Central Asia and there is enormous pressure on Colombia to
  sign an agreement for testing of the coca-killing fungus F.
  oxysporum.

       The potential target acreage is in excess of one million
  hectares, and the US envisions its wide use in Asia and Latin
  America.

       The US claims that the pathogens are environmentally
  safe, are host-specific and don't present any danger to
  humans. But these claims are dubious, charges the Sunhine
  Project.

       Biodiversity concerns include the impact of altering
  fungi populations on highly fragile ecosystems, the impact on
  non-target plant species, on soil ecology and pollinators,
  difficulties of control or withdrawal once released, toxicity
  problems, lack of clarity about the fungi's 'natural
  occurrence' and origin, and the possibility of future
  introduction of living modified organism pathogens.

       The US pathogen-testing has been done primarily to assess
  their effectiveness in killing plants, not for their
  environmental or human safety, nor have the pathogens been
  proved to be safe to other species. Testing for host
  specificity has been very narrow, and has not included close
  relatives of target species.

       Testing has also disregarded complex and fragile
  ecosystems in much of South and South-East Asia and the Andes
  and Amazon basins. And in some US testing, the 'host-specific'
  fungi have attacked both related and non-related species.

       The NGO paper also says that the Agrias (Agrias Claudina)
  butterfly, which depends on coca's wild relatives in the
  Amazonian rainforests, would be endangered.

       The Nairobi meeting of the COP, the NGO briefing paper
  suggests, should declare that the development of any pathogen
  to deliberately kill any cultivated crop is contrary to the
  objectives of the CBD. It should also assess potential impacts
  of narcotic plant pathogens on agriculture.

       The COP should also convey to the UN Commission on
  Narcotic Drugs prior to its March 2001 session the concerns of
  the COP over such international eradication programmes for
  their effects on biological diversity and rights of indigenous
  peoples and local communities. - Third World Network Features

  -ends-

  About the writer: Chakravarthi Raghavan is Chief Editor of
  SUNS (South-North Development Monitor), a daily bulletin, and
  Third World Network's representative in Geneva.

  When reproducing this feature, please credit Third World
  Network Features and (if applicable) the cooperating magazine
  or agency involved in the article, and give the byline. Please
  send us cuttings.

  Third World Network is also accessible on the World Wide Web.
  Please visit our web site at http://www.twnside.org.sg

  2044/2000

-----

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