-Caveat Lector-
The convoluted title of the first article in this post, "No Link Found Between
'Ever' Use of Antidepressants And Breast Cancer Risk", along with its poorly
written and confusing text almost obscures the information it contains.
Here are some statements from this article:
" ...compared with no antidepressant use, the SSRI paroxetine (Paxil)
"was associated with a sevenfold elevation in [breast cancer] risk."
"...tricyclic antidepressant use for 2 years or more was associated with a
twofold elevation in breast cancer risk."
[Tri-cyclics are now standard 'treatment' for fibromyalgia.- M]
"Since women are increasingly taking antidepressants, 'there is cause for concern
regarding the use of antidepressant medications [and breast cancer risk],' the authors
suggest." [see 2nd article. - M]
"Antidepressants may also interfere with enzymes involved in the metabolism of
estrogen and this, too, may influence the development of breast cancer." [see
2nd article. - M]
The second article is just one example of how liberally these toxic
pharmaceuticals are prescribed to women, in this instance for hotflashes caused
by breast cancer treatment.
Additionally, the DSM has included PMS in its diagnostic code a 'new' SSRI,
Serafem [see 3rd article], is being pushed by allopaths for full time use
allegedly to help women with PMS. Serafem is the same drug as Prozac, but
marketed deceptively with a pretty new name.
Is this is a subtle, relatively slow of form of eugenics that avoids any
accountability of causality due to the time frame involved?
~ /\/\
=======================
http://www.medscape.com/reuters/prof/2000/05/05.30/20000530epid006.html
No Link Found Between 'Ever' Use of Antidepressants And Breast Cancer Risk
WESTPORT, May 29 (Reuters Health) - With the exception of paroxetine and
long-term use of tricyclic antidepressants, antidepressant medications do not
seem to be associated with an increased breast cancer risk.
In the May 15th issue of the American Journal of Epidemiology, Dr. Michelle
Cotterchio and colleagues from the University of Toronto, Ontario, Canada, describe
their evaluation of the use of various antidepressants and subsequent risk of breast
cancer in a population-based, case-control study.
Cases were age-stratified as younger or older than 50 at the time of diagnosis of
primary breast cancer. Population controls were randomly sampled from home
owners and tenants living in Ontario.
The investigators observed no increase in breast cancer risk with "ever" use of
antidepressants. However, compared with no antidepressant use, the SSRI paroxetine
"was associated with a sevenfold elevation in [breast cancer] risk." Also, tricyclic
antidepressant use for 2 years or more was associated with a twofold elevation in
breast cancer risk.
As the authors point out, paroxetine may stimulate the secretion of prolactin, "which
has been implicated in the etiology of breast cancer." Antidepressants may also
interfere with enzymes involved in the metabolism of estrogen and this, too, may
influence the development of breast cancer.
Since women are increasingly taking antidepressants, "there is cause for concern
regarding the use of antidepressant medications [and breast cancer risk]," the authors
suggest.
Am J Epidemiol 2000;151:951-957.
Copyright � 2000 Reuters Ltd.
===========================
http://www.cnn.com/2000/HEALTH/cancer/05/23/hot.flashes/index.html
Anti-depressants can ease hot flashes in cancer patients
>From Rhonda Rowland
CNN Correspondent
May 23, 2000
Web posted at: 12:07 p.m. EDT (1607 GMT)
(CNN) -- Breast cancer patients who suffer from hot flashes may get relief from
several types of anti-depressants, researchers at the American Society of
Clinical Oncology conference in New Orleans said.
The drugs, known as SSRIs, include such well-known brands as Zoloft, Paxil and Prozac.
Hot flashes are a frequent side effect of breast cancer treatment. Chemotherapy
can trigger premature menopause in women with the disease, and the anti-estrogen
drug tamoxifen, commonly used to combat breast cancer, can also cause hot flashes.
That side effect can be disruptive and frustrating, said breast cancer patient
Michelle Tennyson, who took part in a pilot study of Paxil. "You lose your
concentration. Things that you try to accomplish, it's very difficult until the
hot flash has subsided."
Although estrogen replacement therapy is a proven remedy for hot flashes, it can
increase the risk of breast cancer.
"Patients don't want to take it and physicians don't want to give it, primarily
because of concern of what estrogen will do to breast cancer," said Dr. Charles
Loprinzi of the Mayo Clinic.
But the anti-depressants seemed to help.
"I started feeling the effects almost immediately," said Tennyson. "I would say
(within) three, four days tops my hot flashes started lessening."
The drug showed other benefits, as well. "The women also reported improvement in
depression scores -- and sleep. The sleep scores improved significantly, as well
as quality of life," said Dr. Vered Stearns of Georgetown University's Lombardi
Cancer Center.
In the largest study to date, researchers found that a similar drug, venlafaxine
(marketed as Effexor), reduced hot flashes by 60 percent when taken in low dosages.
There were few negative side effects -- and an unanticipated positive one.
"Lo and behold, the libido was improved in all the women in the study whether
they were on placebo or venlafaxine, and there was a tendency for an improvement
more with women on the drug," Loprinzi said.
There's even evidence the anti-depressants can relieve hot flashes in men who
have prostate cancer.
Although studies have been done primarily in women who have survived breast
cancer, doctors believe healthy women concerned about getting the disease can
also treat their hot flashes with anti-depressants.
A study last week reported some success combatting hot flashes in breast cancer
patients with the blood pressure drug clonidine.
===========================
http://www.abcnews.go.com/sections/living/DailyNews/lily000706.html
Mood Drug Approved
FDA says the Drug Serafem is OK to Combat PMS
I N D I A N A P O L I S, July 6 � Pharmaceutical maker Eli
Lilly and Co. today said it won U.S. regulatory approval
for Sarafem, the first prescription drug to treat women
who experience severe mood and physical symptoms
during their menstrual cycles.
Sarafem contains fluoxetine hydrochloride, the same
active ingredient found in Prozac, Lilly�s blockbuster
antidepressant drug.
Lilly said the additional trademark will help with
educational efforts for this condition, known as premenstrual
dysphoric disorder (PMDD), while reducing confusion about
the differences between depression and PMDD.
In clinical studies, women treated with Sarafem
experienced statistically significant improvement in mood
and physical symptoms, as well as social functioning,
compared with women taking placebo. These improvements
were demonstrated by the first menstrual cycle on treatment.
Copyright 2000 Reuters.
===========================
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