-Caveat Lector-

                                They're Taking the Joy Out of Soy

                                Does soy shrink the brain? Leave you anemic? Promote
                                rather than prevent cancer? Interfere with your thyroid
                                hormones? Is soy a toxin, a food or a drug? If you eat 
soy,
                                look out, here come the soy bashers. And you won't 
believe
                                who they are.

                                By Bill Sardi - Health Reporter Knowledge of Health, 
Inc.
                                May 2000
                                c. 2000 The Townsend Letter For Doctors
                                http://www.tldp.com/issue/11_00/joysoy.htm 12-29-00


                             It went from being the darling of the natural products
                             industry to being labeled as a potential toxin. Not
                             even a year ago it was heralded in Time Magazine
                             as the bean that brought down cholesterol and the
                             risk of heart disease. Time Magazine said the Food
                             & Drug Administration was soon to approve a health
                             claim for soy protein - that it reduced cholesterol for
                             people with elevated fatty plaque levels in their
                             blood circulation. Just 1.5 ounces of soy, said Time,
                             can lower both total and LDL "bad" cholesterol
                             levels. [The Joy of Soy, Time Magazine, June 7,
                             1999]

                             What a joy, that soy, a natural food product, would
                             gain such credibility that the FDA would grant a
                             health claim for it. It was time for a soy festival. The
                             normally pro-pharmaceutical FDA had finally
                             succumbed to the reality that foods are a good way
                             to prevent and even cure disease. The FDA says
                             scientific studies confirm that 25 grams of soy has a
                             significant cholesterol-lowering effect.* There was
                             an asterisk attached to the FDA announcement
                             however (see below). A soy burger has 9 to 18
                             grams, and soy milk about 4 to 9 grams of soy
                             protein, according to the Soyfoods Association of
                             North America. The cardiovascular health claim was
                             issued October 26, 1999. [FDA T99-48 Talk Paper]

                             Just a relatively short time ago soy was considered
                             a yucky un-American food. But today two-thirds of
                             American consumers now believe it is healthy to
                             consume soy, which is a big jump from the 14% who
                             felt so in 1997. Soy sales were over $1 billion in
                             1997 and are expected to soon jump over the $2
                             billion mark. Health Products Business Magazine
                             reports that the number of new soy beverages is
                             growing at an astounding pace. More soy, more
                             soy!

                             But no sooner had the FDA approved a
                             cardiovascular health claim for soy protein than the
                             critics came out of the woodwork, and not from
                             places one would expect. The greatest criticism of
                             soy has come from natural health advocates
                             themselves. Hold up on that soy protein bar, the
                             tofu scramble and the soy milk. You might come
                             down with Alzheimer's disease, your growing
                             children may shows premature signs of puberty,
                             your thyroid gland may malfunction and your body
                             may not be able to absorb essential minerals,
                             according to reports on soy now circulating in
                             natural health publications.

                             It took less than a month from the date of the
                             issuance of a soy health claim for a bombshell to hit
                             the soy industry. On November 19, 1999, the
                             Honolulu Star Bulletin reported on a study
                             conducted by Lon White, MD, MPH, formerly of the
                             National Institute on Aging and now with the Pacific
                             Health Research Institute, in Hawaii. Dr. White and
                             his colleagues indicated tofu (processed bean curd)
                             could induce "brain aging." Just two servings per
                             week could be harmful said the subheadline. The
                             newspaper report was generated from an abstract
                             of a presentation at the Third International
                             Symposium on the role of soy in Preventing and
                             Treating Chronic Disease. [Journal American
                             College of Nutrition 19: 242, 2000] Data from that
                             report linked tofu consumption with Alzheimer's
                             disease and low brain weight upon autopsy.
                             [http://starbulletin.com/1999/11/19/news/story4.html]

                             By April 29 of this year, Fox News published its
                             version of the soy debate, acknowledging that soy
                             products like tofu and tempeh have "moved out of
                             the vegetarian ghetto," but also warned that some
                             experts claimed that "soy can mimic powerful human
                             hormones and yield unpredictable results." The
                             wind was changing. Was the soybean craze just a
                             fad? Fox News quoted Dr. Lon White as saying that
                             soy isoflavones, one of the active hormonal
                             ingredients in soy, are "true drugs that are sold
                             without warning." [Fox News April 29, 2000]

                             David Zava, PhD, a biochemist, chimes in on the
                             anti-soy bandwagon in the www.JohnLeeMD.com
                             newsletter. A specialist in breast cancer, Zava
                             accurately points out that occasional soy
                             consumption is probably the best course to get the
                             benefits out of soy without any undesirable side
                             effects. But he, unfairly and inaccurately
                             characterizes some of the components of soy as
                             being nothing short of poison. Zava says soy
                             contains allergens, mineral blockers, enzyme
                             inhibitors, hormone modifiers, and iodine blockers
                             that interfere with normal thyroid function. Zava
                             says soy is a medicine in moderation and a potential
                             poison in excess. [www.johnleemd.com] The
                             wording is alarming. Soy is beginning to be
                             compared to hemlock.

                             Sally Fallon and Mary E. Enig, from the Weston A.
                             Price Foundation in Washington DC, write in the
                             April-May edition of Nexus Magazine and the July
                             and August/September issues of TLfDP that soy is
                             not a perfect food (nobody said it was). They repeat
                             claims that it contains anti-nutrients and toxins,
                             which inhibit digestion block and absorption of
                             vitamins and minerals. Fallon and Enig believe most
                             of the information consumers read about soy is
                             "propaganda."

                             They say, until a few decades ago, soy was
                             considered unfit to eat, even in Asia. These
                             self-appointed soy antagonists claim the enzyme
                             inhibitors in soy cause pancreatic cancer (not so),
                             and that other components in soy induce clumping
                             of red blood cells. They admit most of the
                             growth-depressants in soy are removed in
                             processing and fermentation, but not completely
                             eliminated. The very interest in soy for cancer
                             prevention emanates from its ability to thwart growth
                             of tumors.

                             While Fallon and Enig acknowledge that the
                             Japanese and Asians have lower rates of breast,
                             prostate and colon cancer and that they eat 30
                             times more soy than North Americans, they also
                             indicate the Japanese have higher rates of other
                             types of cancer, particularly esophageal, stomach,
                             thyroid, pancreas and liver cancer. They give the
                             misimpression that soy prevents some tumors and
                             promotes others. This just isn't an accurate
                             characterization. The stomach cancers in Japan are
                             attributed to the consumption of pickled, smoked
                             and salted meats and fish as well as raw sushi that
                             may contain parasites. The frying of meats
                             promotes the development of carcinogens. The
                             cancer-promoting agents in these foods can actually
                             be countered by the inclusion of soy protein with
                             ground meat prior to frying. [Basic Life Science 52:
                             105-18, 1990] A hidden epidemic among males in
                             Japan is that of alcoholism, as well as rampant
                             tobacco use, which would be likely causes of liver,
                             esophageal and stomach cancers. Instead, Fallon
                             and Enig imply that soy is a hidden carcinogen in
                             Japan.

                             Fallon and Enig cite the work of Mark Messina,
                             author of The Simple Soybean and Your Health
                             (Avery Publishing 1994], who reviewed 26 animal
                             studies at the Third International Soy Symposium.
                             According to Messina, 65% of these studies confirm
                             the protective properties of soy against cancer.
                             Fallon and Enig claim that Messina purposely left
                             out a 1985 study by Rackis which showed that soy
                             increases the risk of pancreatic cancer in rats.
                             [Advances Experimental Medicine Biology 199:
                             33-79, 1986] At a workshop conducted by the
                             National Cancer Institute, researchers pointed out
                             that the pancreas of a few species of animals,
                             notably rats and chicks, are extraordinarily sensitive
                             to dietary protease inhibitors as found in soy. This
                             effect has not been demonstrated in other species
                             such as hamsters, mice, dogs, pigs, and monkeys
                             and is "not expected to occur in humans," says the
                             report. Human populations that consume high levels
                             of soy exhibit decreased rates of pancreatic cancer.
                             [Cancer Research 49: 499-502, 1989] While the
                             enzyme (protease) inhibitors in soy protein increase
                             the weight of the pancreas, they do not appear to
                             produce lesions, abnormal growths or DNA
                             abnormalities among rats. [Journal Nutrition 117:
                             247-52, 1987]

                             One wonders why Fallon and Enig included in their
                             anti-soy epitaph the story of New Zealand bird
                             breeders Richard and Valerie James. The James'
                             apparently purchased a new type of bird food that
                             contained soy, which made their birds sick, impaired
                             their fertility and changed the coloring of their
                             feathers. The James' related these symptoms of
                             illness to those of their young children, who had
                             been fed soy-based formula. The flock of birds
                             under their care was restored to health by the
                             elimination of the soy-based bird food. But heavens,
                             you don't see birds naturally eating soybeans. They
                             know better. It's obvious the James' knew less about
                             bird feed than their feathered pets! That the James'
                             children were intolerant to soy and may have had
                             soy allergy, or that they may have had health
                             problems unrelated to soy, serve as more likely
                             explanations.

                             Fallon and Enig go on to quote Dr. Claude Hughes'
                             animal research concerning soy isoflavones and
                             thyroid function. Hughes claims his work will be
                             "somewhat predictive of what occurs in humans."
                             But there are differences between animal and
                             human studies, particularly when it comes to soy.
                             Scientists cannot infer that animal data applies to
                             humans. Remember Thalidomide, the drug that
                             caused all the birth defects in Europe? The data on
                             that drug checked out on animals, but among
                             pregnant women interfered with their offspring's
                             development.

                             Fallon and Enig cite 68 scientific references in their
                             Nexus Magazine report. The 40 scientific journal
                             reports cited were published on average 13 years
                             ago, with many dating back to the 1970s. Among
                             the authoritative references listed in support of their
                             report were "Cheese Marketing News" and "Natural
                             Health News published by L & H Vitamin Company."
                             The Weston Price Foundation website, of which
                             Fallon is president, claims their purpose is to dispel
                             health myths. Yet a report on their own website
                             indicates "the New Zealand government is
                             considering removing soy formula from the market
                             and making it available only by prescription," and
                             lists a citation number #58. Their claim may be true,
                             but when the reader looks for the citation in the end
                             notes, it is missing. So the reader has to wonder
                             why. It appears that Fallon and Enig are making a
                             career out of bashing soy, but are they backing up
                             their opinions with good science?

                             Much of Fallon and Enig's criticism is generated
                             from reports on the use of soy infant formulas. In
                             1998, K.O. Klein of the Department of Clinical
                             Science at the A.I. duPont Hospital for Children in
                             Wilmington, Delaware, reported that soy-based
                             infant formulas had been used for over 60 years
                             and fed to millions of infants worldwide and studied
                             in controlled research. Klein says the medical
                             literature provides "no evidence of endocrine effects
                             in humans from infant consumption of modern
                             soy-based formulas. Growth is normal and no
                             changes in timing of puberty or in fertility rates have
                             been reported in humans who consumed soy
                             formula as infants." [Nutrition Reviews 56: 193-204,
                             1998] The Journal of Pediatrics also conducted an
                             earlier study that came to a similar conclusion.
                             [Journal Pediatrics 124: 612-20, 1994]

                             With no supporting evidence, Fallon and Enig state
                             that learning disabilities among male children have
                             reached epidemic proportions and that soy infant
                             feeding, which began in the 1970s, "cannot be
                             ignored as a probable cause for these tragic
                             developments." Yet no citations are listed to back
                             up their claim. They go on to say that one percent of
                             all girls show signs of puberty before the age of
                             three and quote a 1997 report in the Journal of
                             Pediatrics. But that report makes no mention of soy.

                             Fallon and Enig also make the claim that Asians
                             have lower rates of osteoporosis than Westerners,
                             not because of soy consumption but because their
                             diet provides plenty of vitamin D from shrimp and
                             seafood and plenty of calcium from bone broths.
                             They provide no references for this claim. They go
                             on to claim that high rates of osteoporosis in
                             Western society are attributed to the substitution of
                             soy oil for butter. They advocate butter as a
                             traditional source of vitamin D that helps to build
                             strong bones.

                             Butter only provides about 56 units of vitamin D,
                             and shrimp about 152 units of vitamin D per 100
                             gram serving, which are almost insignificant
                             according to the latest reports on the need for
                             vitamin D. [US Department of Agriculture data] Skin
                             exposure to sunlight is the primary source of vitamin
                             D. Even sunlight-deprived women who consume a
                             diet that provides 600 IU of vitamin D/day have
                             been found to be lacking in this essential nutrient.
                             [Journal Internal Medicine 247: 260-68, 2000]
                             Recent reports indicate blood levels of vitamin D
                             don't even begin to rise till 4000 IU of vitamin D is
                             consumed. [American Journal Clinical Nutrition 69:
                             842-56, 1999] The textbooks need to be re-written
                             for vitamin D, and Fallon and Enig are using
                             out-dated information. Furthermore, butter raises
                             cholesterol. [European Journal Clinical Nutrition 52:
                             650-54, 1998]

                             Did all of these negative scientific reports on soy
                             somehow escape the attention of the FDA
                             reviewers? Is the FDA run by individuals who are
                             completely beholden to commercial interests? The
                             Federal Register, October 26, 1999, Volume 64,
                             Number 206, provides a 66-page discussion on the
                             positive and negative reports concerning soy and
                             health in relation to the approval by the Food &
                             Drug Administration that soy protein helps to reduce
                             cardiovascular risk by lowering cholesterol. The
                             report, written by the Food & Drug Administration,
                             cites 167 pertinent scientific studies.

                             According to an FDA scientific review, soy does not
                             interfere with childhood growth, does not cause
                             pancreatic or breast cancer, does not significantly
                             interfere with mineral absorption as long as dietary
                             consumption is adequate, does not induce early
                             puberty, and does not interfere with fertility. Soy
                             may induce allergies, but that is not sufficient
                             reason to ban it from the marketplace.
                             Epidemiological studies do not confirm that soy
                             accelerates the rate or incidence of brain aging nor
                             does soy increase the prevalence of thyroid
                             disorders. There is a consistent body of scientific
                             evidence that soy protein consumption results in a
                             significant reduction in total and LDL cholesterol for
                             those whose cholesterol is elevated (above 250 mg
                             per deciliter blood sample).* Approximately 25
                             grams of soy is needed to produce this health
                             benefit. This is the asterisk noted earlier in this
                             report. Soy doesn't lower cholesterol among
                             individuals with normal blood fats.

                             It's not like soy hasn't been investigated thoroughly.
                             Health reporter Jack Challem notes that in a
                             three-year period from 1996-98, over 1000 articles
                             on soy isoflavones were published in medical
                             journals. But once the gate was opened for a health
                             claim for soy (cholesterol reduction), the rest of the
                             still-to-be-confirmed health claims were ushered in.
                             Some scientific reports indicate soy can reduce hot
                             flashes among menopausal females, promote bone
                             formation and may reduce the risk of cancer.
                             Consumers are likely to think that if a little bit of soy
                             is OK, then more is even better.

                             The natural health gurus are correct on one point.
                             Soy is being over-promoted by billion-dollar
                             companies that grow the beans. Estrogenic
                             compounds are found in other natural foods such as
                             alfalfa sprouts and sunflower seeds, but they aren't
                             being aggressively marketed by multi-national
                             agricultural companies. One of these corporate
                             giants uses shill companies as a front to their soy
                             promotion efforts so as to hide their involvement.
                             The United Soybean Board works more openly to
                             get more soy into the diets of school lunch
                             programs. [www.soyfoods.com] Because the FDA
                             approved soy as a healthy food that reduces
                             cholesterol among adults with high blood fats is no
                             reason to promote it as an alternative source of
                             protein for growing children. Its growth inhibitors
                             and mineral chelators aren't ideally appropriate for
                             children.

                             But to show you how confusing the debate on soy
                             gets, consider the following two quotations from
                             health experts:

                             On December 9, 1999, Doctor's Guide on the
                             internet reported that there is no clear-cut evidence
                             that estrogens from plants such as soy actually
                             prevent breast cancer. Walter Willett, MD, DrPH,
                             Chairman of the Department of Nutrition and
                             Professor of Epidemiology and Nutrition at Harvard
                             School of Public Health in Boston said "a few
                             studies even found that phyto (plant) estrogens
                             promote cancer. We do not know if plant estrogens
                             increase or decrease risk."

                             Yet Herman Adlercreutz MD of the University of
                             Helsinki says there is "no evidence in the literature
                             suggesting that phytoestrogens, present in amounts
                             found in human foods, could have biological effects,
                             or stimulate already existing cancer, and there is
                             also no evidence that such phytoestrogens could
                             initiate cancer." [Annals of Medicine 29: 95-120,
                             1997]

                             So what are we to conclude? Soy does/doesn't,
                             prevent cancer. With that kind of doubt being
                             created on its cancer prevention benefits, and its
                             safety being clouded by reports that allege soy
                             causes brain disease, one wonders if consumers
                             will even feed soy to their pets. Who knows, some
                             environmentalists may soon ask for the soy toxin to
                             be removed from garbage dumps.

                             Who is behind the scenes in the soy debate? Who
                             can profit? Pharmaceutical companies don't like the
                             idea of a food competing with the patented hormone
                             blockers, like raloxifene and Tamoxifen. In the
                             September 1998 issue of Nutrition Science News,
                             health reporter Jack Challem notes that tamoxifen
                             and raloxifene reduce the risk of breast cancer but
                             tamoxifen increases the risk of endometrial cancer
                             and blood clots in the lungs, and with raloxifene are
                             more likely to suffer from hot flashes and leg
                             cramps. Tamoxifen increases the risk of going blind
                             from cataracts by about 400%. [American Journal
                             Ophthalmology 125: 493-501, 1995]

                             Let's see if we can make some sense of the soy
                             debate.

                             1. The reason why soy gained the attention of
                             Western health researchers is because the
                             American diet is almost completely devoid of
                             phytoestrogens. Hormones can get out of balance,
                             and hyperthyroid and over-production of estrogen
                             can produce symptoms and pose health problems
                             as much as low hormone levels. A small amount of
                             plant estrogens in the diet may act as hormone
                             controlling agents.

                             2. Like any food, soy may induce allergies. So does
                             cow's milk, eggs, wheat, corn and fish. But nobody
                             is warning the public away from these foods.

                             3. While mother's milk is widely promoted for
                             newborns, when baby needs to be weaned, cow's
                             milk or soy-milk formulas are often relied upon.
                             Cow's milk appears to result in superior bone
                             mineral content, but soy formula appears to produce
                             similar bone mineral content to breast milk. [Journal
                             Pediatrics 113: 205-07, 1988; Journal Pediatrics
                             110: 687-92, 1987] Soy milk formula appears to
                             produce similar weight gain (growth rates) as
                             produced with cow's milk formula in young infants.
                             [Pediatric Research 15: 1240-44, 1981] Soy infant
                             formulas can be modified to suspend minerals and
                             thus improve bone mineral content. Modified soy
                             formula has been shown to improve bone mineral
                             content among infants comparable to cow's milk
                             formula. [American Journal Diseases Children 146:
                             1302-05, 1992]

                             For infants who are allergic to cow's milk, soy milk is
                             the alternative of choice. But even one in four
                             allergic infants have problems tolerating soy
                             formula. Better to look into whey milk formulas.
                             Whey milk is probably superior to soy milk when it
                             comes to minimizing allergic reactions among
                             infants. [Arerugi 46: 1044-51, 1997] In one study
                             84-99% of infants who were allergic to cow's milk
                             were able to consume whey protein formula without
                             allergic reaction. [Journal Pediatric
                             Gastroenterology Nutrition 26: 398-401, 1998] In
                             another study, whey milk formula reduced the
                             incidence of allergy among 6-month old infants by
                             over 5 times compared to cow's milk. [European
                             Journal Pediatrics 154: 488-94, 1995] Furthermore,
                             whey appears to produce the same growth rates as
                             cow's milk. [Allergy 51: 192-95, 1996]

                             4. Some of the components of soy have been
                             mistakenly identified as anti-nutrients. For example,
                             IP6-phytic acid, the primary mineral chelator in soy,
                             was branded as an anti-nutrient because it blocks
                             mineral absorption. Minerals, particularly iron,
                             calcium and zinc, are important during childhood
                             growth. It is easy to improve iron absorption in soy
                             infant formulas by adding some vitamin C. [Pediatric
                             Research 36: 816-22, 1994] But adults tend to
                             over-mineralize as they grow older. The threat of
                             iron overload is universal in male adults and
                             postmenopausal females. Calcium tends to
                             accumulate in the joints (arthritis), heart valves
                             (mitral valve), kidneys (kidney stones), blood
                             vessels (atherosclerosis) and lens of the eye
                             (cataracts) with advancing age. So there is a need
                             for dietary mineral chelators, to prevent
                             calcifications and iron-induced oxidation in living
                             human tissues, particularly with advancing age. In
                             1987 Ernst Graf, PhD, was the first to describe
                             IP6-phytic acid, found in whole grains and nuts, as a
                             potent antioxidant and mineral chelator. It is the only
                             antioxidant known that can completely counter the
                             adverse effect posed by the hydroxyl radical, a free
                             radical species involved in all cancers. [The Lancet,
                             September 19, 1987] Most soy protein products
                             already have undergone processing to remove most
                             of the IP6-phytic acid anyway. [Acta Paediatrica
                             402: 105-08, 1994] The removal of IP6-phytic acid
                             from soy increases iron absorption. [American
                             Journal Clinical Nutrition 60: 567-72, 1994]

                             The IP6-phytic acid in soy has been found to reduce
                             the risk of colon cancer in an animal study via its
                             ability to chelate iron. [Proceedings Society
                             Experimental Biology & Medicine 221: 80-86, 1999]
                             The IP6-phytic acid in soy may be the primary
                             ingredient that helps to control cholesterol. [Journal
                             Nutrition 125: 606-611S- 1995]

                             IP6-phytic acid is not only found in soy, it is
                             provided in other whole grains, particularly bran. But
                             no one is proposing that bran is toxic because of its
                             IP6-phytic acid content. Cow's milk (probably due to
                             its lactoferrin content), and eggs also tend to
                             decrease the bioavailability of iron from plant foods.
                             [Federal Proceedings 42: 1716-20, 1983]

                             The primary reason why adults do not get enough
                             of some minerals with advancing age is the
                             diminished production of hydrochloric acid, not the
                             inclusion of IP6-phytic acid in whole grains and soy.
                             [Advances Experimental Biology Medicine 249:
                             173-84, 1989] Soybean compounds such as
                             IP6-phytic acid, protease inhibitors and isoflavones,
                             among others, appear to reduce the incidence of
                             colon, prostate and breast cancer. [Journal Nutrition
                             125: 733-743S, 1995]

                             5. Why get so bothered about soy? Indeed, spices
                             such as thyme, oregano and turmeric bind with
                             estrogen or progesterone and are thus known to be
                             hormone blockers. [Proceedings Society
                             Experimental Biology Medicine 21: 369-78, 1998]
                             Even though the American diet is said to be lacking
                             in soy phytoestrogens, beer contains significant
                             amounts of isoflavones (probably from hops).
                             [Steroids 63: 14-20, 1998]

                             6. Science backs the consumption of soy protein
                             and/or soy extracts (phytoestrogen-isoflavones) for
                             males with prostate tumors. In immune-depressed
                             rodents whose prostate glands were inoculated with
                             human cancer cells, soy significantly reduced the
                             size of tumors and the number of blood vessels that
                             feed tumors. [Journal Nutrition 129: 1628-35, 1999]

                             7. There is a great difference between animal and
                             human studies. Soybean cereal has been shown to
                             interfere with the growth of young rodents.
                             [Medicina 59: 747-52, 1999] But in infants, there
                             was no difference noted in weight gain nor
                             pancreatic enzyme production when fed soy or a
                             whey protein formula. [Scandinavian Journal
                             Gastroenterology 32: 273-77, 1997] Be wary of
                             so-called experts who only quote animal data to
                             support their claims that soy is toxic or unhealthful.

                             8. The fact that isoflavones in soy are reduced
                             significantly by their first pass through the liver
                             following ingestion, limits their hormonal effects,
                             particularly on children. [Proceedings Experimental
                             Biology Medicine 217: 386-92, 1998] Recent data
                             shows that neither soy, nor soy isoflavones, exert
                             estrogenic effects on vaginal tissues in
                             postmenopausal females. [Journal Clinical
                             Endocrinology 84: 3479-84, 1999] In monkeys, soy
                             phytoestrogens reduced cholesterol but did not
                             affect the reproductive hormones. [Journal Nutrition
                             126: 43-50, 1996]

                             9. A recent study conducted among 31 patients with
                             high cholesterol, who were provided 33 grams per
                             day of soy protein (providing 86 mg of isoflavones),
                             reveals that LDL "bad" cholesterol levels were
                             significantly reduced even among subjects who
                             were already taking vitamin E supplements
                             (400-800 IU). The soy protein did not increase the
                             risk of hormone-induced cancers. [Metabolism 49:
                             537-43, 2000]

                             10. Soy is a known goiterogen. It may interfere with
                             iodine, a trace mineral required for thyroid function.
                             [Biochemical Pharmacology 54: 1087-96, 1997]
                             Infants with congenital low thyroid output, when
                             placed on soy formula, need to have their thyroxine
                             dose increased. [Journal American College Nutrition
                             16: 280-82, 1997] Infants with normal thyroid output
                             need not be concerned. But adults who are on
                             thyroid hormone replacement would be wise to
                             review their consumption of soy with their physician
                             and to be aware of symptoms such as fatigue and
                             loss of hair, which may occur with low thyroid.

                             11. What about the link between brain shrinkage
                             and soy consumption? Dr. Lon White MD, the lead
                             researcher who reported this link, compromised his
                             own credibility when he was quoted as saying:
                             "Those who ate a lot of tofu, by the time they were
                             75 or 80 looked five years older." Tell us Dr. White,
                             did you count the wrinkles? We await corroborative
                             research studies.

                             12. Stephen Holt, MD, writing in Natural Pharmacy,
                             has done the best job of sorting out information
                             about soy. He says soy protein should be
                             distinguished from the soy extracts or isoflavones.
                             Consumption of up to 120 milligrams of soy
                             isoflavones from soy foods should not be
                             considered worrisome. He says phytoestrogens in
                             soy are far weaker than the potent synthetic or
                             natural estrogens commonly prescribed to women
                             for menopause symptoms. But he does caution
                             against excessive consumption of soy isoflavones in
                             food supplements or from fermented sources
                             (tempeh, miso) which Fallon and Enig advocate. His
                             guess is no more than 45 milligrams of conjugated
                             isoflavones from fermented or supplmental sources
                             daily. [Natural Pharmacy, April 2000]

                             While soy has gained the most attention because it
                             is backed by powerful agribusiness, its cousin
                             lignan may soon become a more desirable
                             phytoestrogen. Herman Adlercreutz, one of the
                             world's top isoflavone researchers, emphasizes the
                             importance of other phytoestrogens. "Don't forget
                             the lignans," he says. [Nutrition Science News,
                             September 1998] We can see why researchers are
                             turning their attention to lignan.

                             Lignan is a normal component of the diet, albeit it is
                             only consumed in small amounts. It is a
                             phytoestrogen that does not interfere with thyroid
                             function. Lignan is most abundant in flaxseed.
                             Lignans in flaxseed have been compared to
                             Tamoxifen, a hormone-blocking drug often
                             prescribed in cases of breast cancer. [Cancer
                             Letters 125: 69-76, 1998] Adlercreutz says the
                             areas of the world where consumption of
                             isoflavones and lignans are high have low rates of
                             prostate, breast and colon cancer. Animal
                             experiments confirm that lignans and isoflavones
                             prevent cancer in blood vessel disease. [Annals
                             Medicine 29: 95-120, 1997] When rates of disease
                             are investigated by the type of phytoestrogen, both
                             isoflavones derived from soy, and lignans found in
                             flaxseed, whole-grain rye bread, berries and some
                             vegetables, are attributed to the reduction in breast,
                             prostate and colon cancer. Where consumption of
                             lignan is low (USA, Finland, Sweden, Australia)
                             breast cancer levels are high. [Baillieres Clinical
                             Endocrinology Metabolism 12: 605-23, 1998]

                             In one study prostate tumor cells were injected into
                             rodents who were placed on different diets. Only
                             50% of the sites injected with tumor cells grew
                             tumors among the animals on soy, and only 30% of
                             injection sites exhibited tumors among the animals
                             that consumed lignan-rich rye bran. The tumors that
                             did grow were smaller in the animals consuming soy
                             and rye bran and there was less secretion of
                             prostate specific antigen (PSA). The addition of fat
                             to the rye bran diet reduced its protective effect
                             against prostate cancer. [Prostate 42: 304-14, 2000]

                             In a study where rodents were given a
                             tumor-promoting agent, a diet enriched in soy did
                             not reduce the number of colon tumors (1.38 tumors
                             per animal) compared to a diet low in soy
                             isoflavones (1.36 tumors per animals. But a
                             lignan-rich rye bran diet did reduce the number of
                             tumors! (0.17 tumors per animal). [Carcinogenesis
                             20: 927-31, 1999]

                             Summary

                             Soy is not hemlock. It is not a toxin, nor does it
                             contain toxins. Soy is like table salt. Overuse can be
                             troublesome. Learn to use it sparingly. If you are
                             looking for lignans in your diet, throw in some
                             flaxseeds, or cold-pressed lignan-rich flaxseed oil.
                             Lignan may soon create a greater stir among health
                             advocates than soy.


                             Correspondence:

                             Bill Sardi Health Reporter - Knowledge of Health
                             Email: [EMAIL PROTECTED]


                             Copyright� Townsend Letter for Doctors and
                             Patients 2000 All Rights Reserved
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