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Peace at any cost is a Prelude to War!
Mutant bacteria biowars threaten apocalypse now
Genetic engineers already have it within their grasp to devise a lethal
bio-weapon for terrorists and rogue states, the British science publication
Nature warns this week.
Small changes in the DNA of well-known bacteria and viruses could turn these
agents into mass killers, the journal says.
The publication echoes warnings by a pair of Australian scientists, Dr Ron
Jackson and Dr Ian Ramshaw, who accidentally created an astonishingly
virulent strain of mousepox, a cousin of smallpox, among laboratory mice.
They realised that if similar genetic manipulation was carried out on
smallpox, an unstoppable killer could be unleashed. They decided to publish
their findings in January to draw attention to the potential misuse of
biotechnology.
Nature warns: "Making subtle genetic alterations to existing pathogens to
increase their virulence or durability in the environment, or to make them
harder to detect or to treat with drugs, is within the limits of today's
technology.
"With the decoding of a pathogen's entire genome now commonplace, and
transgenic techniques advancing all the time, some researchers believe that
the sinister potential of biology can no longer be ignored."
Biowarfare - use of germs or viruses such as anthrax or smallpox - has long
been considered by military strategists. However, the risk has increased
thanks to advances in knowledge about how genes work, new techniques for
moving pieces of DNA around, and the relative ease with which a rogue
organisation could build or hire a lab to build such a weapon.
Scientists interviewed by Nature ruled out, for the time being, the ability
to build new, artificial agents from a set of component parts.
A far simpler way would be to tweak the performance of an existing bacteria
to make it more resistant to antibiotics, they said.
The genetic sequences of bacteria such as tuberculosis, cholera, leprosy and
the plague are already in the public domain - as is that of a food poisoning
bug, Staphylococcus aureus, that is already becoming resistant to antibiotics.
By identifying the genes from Staphylococcus aureus that make the bug
resistant, and inserting them into the other bacteria, a scientist could make
a killer for which there would be scant defence.
Dr Willem Stemmer, chief scientist with Maxygen, a California pharmaceutical
research firm, used one of these techniques to explore how resistance genes
work, Nature reports.
He created a strain of the common intestinal bug Escherichia coli that was
32,000 times more resistant to the antibiotic cefotaxime than conventional
strains. He destroyed the superbug in response to the American Society for
Microbiology's concerns about potential misuse.
"It's time for biologists to begin asking what means we have to keep the
technology from being used in subverted ways," said Harvard University
molecular biologist Professor Matthew Meselson, who has often spoken of the
dangers of biowarfare.
Agence France-Presse
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