-Caveat Lector-
Has The Ultimate Cancer Cure
Been Found In India?
The Hindustan Times (6-3-01)
6-6-1
HYDERABAAD - Indian cancer researchers have taken a
giant step on the road to discovering the ultimate cancer
cure by developing a drug that selectively targets the
cancer cells without harming the healthy ones.
Researchers in Kolkata claim that patients in "very
advanced stages" of cancer for whom all other treatments
had failed have been brought back to "excellent" health
with the help of a drug formulation they have developed
after research spanning more than a decade.
"We have what we think magic bullet against cancer,"
says Manju Ray, a biochemist at the Indian Association of
the Cultivation of Science (IACS) where the drug was
developed under a project funded by the Department of
Science and Technology and the Council of Scientific and
Industrial Research.
Most currently available anti-cancer drugs are toxic
because they also damage the normal cells. Ray says the
IACS formulation, containing "Methylglyoxal" as the lead
ingredient, combats only the diseased cells, the cherished
goal of cancer researchers worldwide. Methylglyoxal is a
metabolite in the human body produced during glucose
breakdown.
Others involved in the project are Swapna Ghosh of IACS,
Manoj Kar and Subhankar Ray of the University College
of Science, and Santajit Datta, a medical practitioner.
Results of human trial conducted by them with the new
drug have recently appeared in the Indian Journal of
Physics.
While Americans are going ga-ga with their new
anti-cancer drug "Glivec" - that was featured on the cover
of May 28 issue of Time magazine - the low-profile,
cash-strapped Kolkata researchers have been working
quietly for over a decade shuning publicity until they
obtained proof from human trials nine weeks ago.
According to their published paper, the
Methylglyoxal-based forumulation had "a dramatic positive
effect on the patients".
For instance, the condition of 11 out of the 19 patients
treated - most of them in a very advanced stage when the
treatment began -- are now stated to be in "excellent
physical condition". Five are in stable condition and only
three died during the course of the study.
Since the submission of the paper, the number of patients
treated has crossed 40 mark with more than 70 per cent
success, according to Manju Ray.
Most remarkable fact, according to the scientists was that
Methylglyoxal was successful against different types of
cancer unlike "Glivec" which targets only the chronic
myeloid leukemia.
Those whose health returned to "excellent" condition after
treatment with Methylglyoxal included patients in "a very
advanced stages" of colon cancer, acute myeloid
leukemia, non-Hodgkin's lymphoma, and cancers of ovary,
breast, liver, lung, bone, gall bladder, pancreas and oral
cavity.
The patients were inducted for the trial, from January to
June 2000, after obtaining permission from the Drug
Controller General of India, the scientists said. The drug
was administered orally for about six months with gradual
reduction of daily dosage from the initial 25 milligrams per
kilogram of body weight.
Researchers said development of the drug was preceded
by years of basic research involving human cancer cells in
culture and animal experiments that showed that
Methylglyoxal selectively killed the cancer cells without
affecting normal cells by exploiting "a very significant"
biochemical difference between the two.
Explaining the mechanism of action, the scientists said
cancer cells required a large amount of energy providing
substance called ATP (Adenosine-5-Triphosphate) for
survival.
"Methylglyoxal inactivates the enzyme (Glyceraldehyde-3-
Phosphate Dehydrogenase) needed for ATP production in
cancer cells and thereby starves tem to death. Normal
cells remain unaffected."
Manju ray said that chemists knew Methylglyoxal molecule
for about four decades and its anti-cancer effects in
animals had also been studied. "But surprisingly, no one
bothered to initiate further research leading to human
trials," she said.
The researchers said concern in some quarters about
safety of Methylglyoxal were not borne out from the
clinical trials, which showed that in combination with
protective agent like Ascorbic Acid and vitamins, the drug
Methylglyoxal had no major toxic effect. They said there
was scope for further enhancing the drug's efficacy.
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