-Caveat Lector-

Hepatitis C Could Be Deadlier Than AIDS by 2010
Phil Brennan, NewsMax.com
Tuesday, Aug. 14, 2001
It wasn't discovered until 1989, but hepatitis C is already killing
10,000 people annually, and the Center for Disease Control predicts
that by 2010 it will claim more victims than AIDS.
Between 1993 and 1998 AIDS deaths had dropped to just below 18,000
a year from a high of more than 45,000. During the same period,
hepatitis C infections skyrocketed by a dizzying 260 percent - a
rate of increase that by 2010 will leapfrog it past AIDS as a
killer.

Capable of lurking undetected for as long as 20 years before
symptoms such as jaundice, fatigue and abdominal pain appear,
hepatitis C, by the time it has been diagnosed, is already in its
chronic stage, when serious liver scarring and the threat of cancer
and death exist.

"For now we don't have a way of predicting who will wind up in that
shape," Richard Manch, a liver specialist at Good Samaritan
Regional Medical Center in Phoenix, told Forbes magazine.

Writing in the Aug. 20 issue, Rob Wherry reported that experts do,
however, predict that the number of victims getting treatment for
hepatitis C - 200,000 - could double to 400,000 in a mere four
years.

The disease is contracted through intravenous drug use or blood
transfusions. The only drug capable of treating it -
Schering-Plough's Rebetron - costs a staggering $18,000 annually.

According to Forbes, the drug is a combination of ribavirin and the
anti-cancer drug interferon, which when given separately have
little effect, but in combination help prevent hepatitis C from
spreading by causing it to make defective virus cells. Rebetron
works in 40 percent of hepatitis C infections but carries the risk
of side effects such as depression and anemia.

"Like other plagues, hep-C has stymied scientists," Wherry wrote,
adding that experts have been unable to grow it in the lab.
Moreover, it is tough to prevent it from replicating itself While
so-called protease inhibitors shut down AIDS enzymes by locking
onto readily available toeholds, hepatitis-C's protease is smooth
and drugs slide off it like water off a duck's back.

According to Forbes, a new family of drugs promises to boost cure
rates from 40 percent to 56 percent (a "cure" being defined as six
months virus-free), and some doctors hope to wipe it out entirely.
Unlike HIV, which lives in the nucleus of the cell, hepatitis C
lives outside the nucleus. That easier access gives the new family
of drugs an opportunity to rid the body of hepatitis C, while HIV
drugs can at best suppress the virus.

A big question is why AIDS gets many times the attention of this
deadly disease.

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