-Caveat Lector-

Distinguishing inhaled anthrax from colds, flu

Copyright � 2001 AP Online

By DANIEL Q. HANEY, Associated Press

(November 2, 2001 9:53 a.m. EST) - Doctors have a new clue to help sort
out whether people with coughs and aches have the ominous first signs of
inhaled anthrax or ordinary colds and flu: Anthrax victims don't have runny
noses.

In general, the first symptoms of inhaled anthrax are the same as the flu and
other wintertime viruses - fever, ache, cough, no energy. As a result, some
worry that doctors will prescribe lots of anthrax-killing antibiotics - which do
nothing for colds and flu - just to make sure they don't miss a case of anthrax
in its early, treatable stage.

Symptoms of nasal congestion or runny nose have not been reported in the
inhaled anthrax cases so far. Those symptoms, of course, are common in flu
and many other viruses that cause wintertime respiratory ills. So asking
about it can help doctors rule out anthrax.

The possible overuse of antibiotics worries officials at the Centers for
Disease Control and Prevention, which on Thursday offered some guidance
for doctors who wonder how to tell which is which.

"We will do everything we can to help clinicians sort this out," Dr. Julie
Gerberding said.

No test will reveal anthrax exposure or predict who might develop anthrax in
the near future. Nasal swabs, if given soon enough, can help show whether
anthrax was present in a particular location, but they do not tell doctors
anything about an individual's risk.

So far, the single most important information is the patient's job. Doctors
should be suspicious if patients are postal workers or handle mail, especially
in areas where anthrax has been found.

"I can't emphasize enough the importance of the clinical history of the
occupation and the environment in which the person works," Gerberding
said.

White cell counts also may be elevated in anthrax cases, Gerberding noted.
These readings are likely to be normal or below with viral infections.

However, no single sign or symptom can reveal whether someone has early
inhaled anthrax. Antibody levels eventually rise, but that occurs late in the
infection, after treatment already should have begun.

"We don't want everybody coming in with the flu to get an antibiotic,"
Gerberding said.

Dr. Frederick Hayden, a flu specialist at the University of Virginia, estimated
that 60 percent of flu cases involve runny noses, and the figures are even
higher for most other common respiratory viruses.

"The dilemma will be sorting out the extremely rare case of inhalation anthrax
from this massive background of respiratory viral infections," he said.

Some doctors have promoted the use of flu shots this year because they will
reduce the frequency of symptoms that can be confused with anthrax.
However, many are skeptical about this reasoning. They note that perhaps
90 percent of wintertime flu-like illnesses are cause by neither the flu nor
anthrax. So even those who get flu shots may still come down with flu-like
symptoms from other viruses.

"We really don't want to sell the idea that if you get vaccinated against the flu
... and if you do develop a flu-like illness, then you ought to be more worried
about anthrax," said Dr. Keiji Sukuda, a CDC flu expert.

The best reason to get a flu shot, he said, is to avoid the flu.

To help doctors figure out how to recognize and treat anthrax, the CDC on
Thursday held its second conference called "Anthrax, what every clinician
should know."

The conference will be rebroadcast on the Internet at 5 p.m. Monday.

Medical Editor Daniel Q. Haney is a special correspondent for The
Associated Press.


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