On Sat, 15 Mar 2003, Major Variola (ret) wrote:

> What happens when you fly a low-fuel high speed 727 into a biosafety
> level 4 containment facility?

It will be reduced to rubble. Most of those inside will get killed. 
Sterile containments will be breached. Negligible amounts of pathogens 
will be released. There's a low probability it will result in those 
pathogens actually infecting people in the vicinity (I presume the 
firefighters will be instructed accordingly). The probability of an actual 
runaway infection is indistinguishable from zero -- it's a research 
facility, not munition depot.
 
> Probable answer: not in the threat model considered during design, so it
> can't happen.

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