September 21, 2008.

The Age, Australia - September 22, 2008.

Stem cell find may replace bionic ear.
By Nick Miller

 THE bionic ear is one of Australia's proudest achievements, but 
a Melbourne
researcher's work could take the fight against deafness to a new 
level.  Bryony Coleman, at the Eye and Ear Hospital, is 
conducting world-first research into the potential of stem cells 
to regrow the nerves that connect the ear to the brain.

If successful, the technique could be used to improve the quality 
of hearing in people with cochlear implants - and one day it may 
even help restore hearing to those who are totally deaf.

"Fifty years down the track this might be one of many techniques 
- we might not even need a cochlear implant," Dr Coleman said.

When a rock concert, pneumatic drill or blaring iPod destroys 
some of the tiny, vibrating hairs in the inner ear, the damage 
does not stop there. Each hair cell's destruction leads to the 
death of up to 10 nerves that carry
sound information into the brain.

The bionic ear (cochlear implant) can replace some of the work of 
the hair - but it cannot regrow the nerves.

Enter the stem cell: "precursor" cells that can grow into 
replacement nerve cells. "The theory is that the bigger and 
healthier the nerves, the better the cochlear implant will work," 
Dr Coleman said. "We are using stem cells
to make that bigger and healthier."

Of course, it is more complicated than sticking a bunch of cells 
in your ear. Dr Coleman has to make the cells grow in the right 
place, to connect the hair cell to the brain.

"We have transplanted stem cells into the (inner ear) and they 
survive, but we need to know if they work," she said.

Last month scientists announced that, for the first time, they 
had used gene therapy to regrow the delicate hair cells of the 
inner ear - in mice. Dr Coleman said her work could supplement 
that breakthrough.

The Age




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