With testing amd64  I installed Xfce a few months ago. I can now say that,
for scientific use of the computer, I found Xfce far better than its
father, GNOME. First, Xfce does not take possession of the computer.
Second, I can run preliminary molecular dynamics with CPU-graphical boards
from Xfce. That was not possible from GNOME, which took a lot of RAM and,
worse, gradually eated up all RAM. With GNOME I had to run MD without the
X-server, a slower doing in  trial MD, to prepare the system for the
mainframe.

I only have to check whether gchempaint (a drawing tool for small
molecules) works with Xfce. That is needed.

regards

francesco pietra

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