Hello Jun, Thank you for your report and for your work to improve the architecture support on several projects!
I think this is a good idea for after the "buster" release. Could you prepare a pull request at https://salsa.debian.org/med-team/bowtie2 and we can merge it then? Alternatively we could do a build in the experimental suite, and then you could test building all the packages that have a build-time or run-time dependency on bowtie2 under aarch64. I have a feeling that we may need to adjust some (many?) other packages which is why I advocate for this to wait for the next release cycle. If it goes well, then we could backport the adjustments (or propose for the "buster.1" point release). $ apt-cache rdepends bowtie2 bowtie2 Reverse Depends: ariba unicycler trinityrnaseq |tophat srst2 rsem python-pbalign pbalign paleomix metaphlan2-data metaphlan2 giira gasic Cheers,

