FWIW I'm fairly convinced that the first vulnerable version for CVE-2020-5310 
is 6.0.0, which is the first release that included 
 which introduced 
the overflow when switching away from the safer TIFFTileSize & TIFFStripSize 
in the critical lines.

So you can probably mark 5.4.1 as safe for CVE-2020-5310


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