Hi Stéphane, I've hit the same problem while migrating my Django sites from Debian Buster to Bullseye.
In my case, setting "WSGIApplicationGroup" to "%{GLOBAL}" doesn't help much. But I found another solution, by enabling Daemon mode, as recommended by the Django docs: https://docs.djangoproject.com/en/3.2/howto/deployment/wsgi/modwsgi/#using-mod-wsgi-daemon-mode So I added these two lines in each site (with appropriate domain name) and it works fine: WSGIDaemonProcess example.com WSGIProcessGroup example.com Hope it helps. -- Sébastien Helleu web: weechat.org / flashtux.org irc: FlashCode @ irc.libera.chat