Hi, I was briefly looking into this bug. libskbb-dev did build without any problem on s390x (sbuild also went fine). So, I went on to run the tests for unifrac-binaries and saw a few errors. I have found the root cause of the issue and is currently working on a fix.
More details are here: https://github.com/biocore/unifrac-binaries/issues/92 Thanks, Pranav

