Hi! I'd assume that you're talking about some specific use cases (where and when to add i386 as extra / "foreign" architecture to dpkg) and not generally about i386.
wine 11.0 and onward: you're right, there's no need to add i386 architecture as "foreign" and install i386 packages. I'm currently running version 11.1 with no issues so far. grub-pc and gcc-multilib: grub-pc doesn't depend on gcc-multilib (or I've missed something?). Furthermore, neither grub-pc nor gcc-multilib require packages from foreign architecture, e.g. no i386 packages are required if you're on amd64. -- SY, Konstantin Demin
