Following the references in https://www.nature.com/articles/d41586-021-01968-y
I found this reference https://github.com/RosettaCommons/RoseTTAFold/tags but I admittedly cannot tell that I'd have fully grasped who is doing what and publishes what software where, yet. The context: The biochemistry happens in 3D as proteins (and some functional RNA), while all we easily get are 1D DNA sequence data from which one can predict the sequences of amino acids that form the protein. To get from that polymer of amino acids to the 3D structure one typically looks for patterns of sequences that have been observed in structures that have already been determined. Or one try computing that structure de novo, i.e. without a template, and ... wait. Once we have the protein structures one can better understand the effect of mutations, and start other sorts of simulations, like disturbing protein interactions with compounds, i.e. find new drugs. Best, Steffen
