Same thing here, I can add that none of this work:
- "Send" button
- Ctrl+Enter (shortcut for Send)
- Ctrl+Shift+Enter (shortcut for Send later)

I started thunderbird from terminal to see if something gets logged to
the terminal, but I did not see anything.

By the way, I disabled any extension that had anything to do with the Sending 
or composing functionality.
Tried in Gnome, Kde(Plasma), XFCE, same behavior.

Downgrading to 1.38.* (via synaptic GUI) worked also for me.

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https://bugs.launchpad.net/bugs/1604394

Title:
  send button does not work

Status in thunderbird package in Ubuntu:
  Confirmed

Bug description:
  On 19/7/16 I accept updates for thunderbird 38 to 45.2, using the
  standard ubuntu update process on 16.04.1 xenial, kernel
  "4.4.0-31-generic #50-Ubuntu SMP Wed Jul 13 00:07:12 UTC 2016 x86_64
  x86_64 x86_64 GNU/Linux"  (followed by a lightning extension update).

  I could not send any email, nor spell check.  Nothing happened when I
  pressed the buttons.  So I downgraded to 1.38.6.0+build1-0ubuntu1 (and
  replaced the lightning extension).  All now works again.  I had to
  force and lock this version using synaptic.

  I don't see how this can be anything to do with my setup, since 38
  works OK.

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