Unforunately, I believe this is an issue with the MOTU Ultralite AVB.
Several people are actively trying to solve it over here:
https://linuxmusicians.com/viewtopic.php?f=6&t=18046

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https://bugs.launchpad.net/bugs/1782597

Title:
  Output of my USB audio device gets progressively bitcrushed

Status in alsa-driver package in Ubuntu:
  New

Bug description:
  After a while (between 5 and 10min), the output of my MOTU Ultralite
  AVB usb sound card gets dirtier and faintier (sounds like a
  bitcrushing effect) until there is no sound anymore. Sometimes muting
  the sound and switching to internal audio device and back to the motu
  will make the sound clean again, sometimes not. The Motu works ok with
  windows.

  ProblemType: Bug
  DistroRelease: Ubuntu 18.04
  Package: alsa-base (not installed)
  ProcVersionSignature: Ubuntu 4.15.0-23.25-generic 4.15.18
  Uname: Linux 4.15.0-23-generic x86_64
  NonfreeKernelModules: nvidia_modeset nvidia
  ApportVersion: 2.20.9-0ubuntu7.2
  Architecture: amd64
  CurrentDesktop: ubuntu:GNOME
  Date: Thu Jul 19 16:52:34 2018
  InstallationDate: Installed on 2016-05-01 (809 days ago)
  InstallationMedia: Ubuntu 16.04 LTS "Xenial Xerus" - Release amd64 
(20160420.1)
  SourcePackage: alsa-driver
  Symptom: audio
  Symptom_Card: UltraLite AVB Baptiste - UltraLite AVB Baptiste
  Symptom_PulseAudioLog:
   juil. 19 16:29:48 multivac pulseaudio[1945]: [autospawn] core-util.c: Home 
directory not accessible: Permission non accordée
   juil. 19 16:29:48 multivac pulseaudio[1945]: [autospawn] lock-autospawn.c: 
Impossible d'accèder au verrou autonome.
   juil. 19 16:29:48 multivac pulseaudio[1945]: [pulseaudio] main.c: Failed to 
acquire autospawn lock
   juil. 19 16:30:00 multivac dbus-daemon[1441]: [system] Activating via 
systemd: service name='org.freedesktop.RealtimeKit1' 
unit='rtkit-daemon.service' requested by ':1.52' (uid=108 pid=3980 
comm="/usr/bin/pulseaudio --start --log-target=syslog " label="unconfined")
   juil. 19 16:30:06 multivac systemd[1]: session-c1.scope: Killing process 
3980 (pulseaudio) with signal SIGTERM.
  Symptom_Type: Sound works for a while, then breaks
  Title: [USB-Audio - UltraLite AVB Baptiste, playback] fails after a while
  UpgradeStatus: Upgraded to bionic on 2018-05-29 (50 days ago)

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