After debugging a lot I found that the problem is caused by the Add-on
"Subject Manager 1.1.1". After disabling this plug-in sending works fine
again.

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https://bugs.launchpad.net/bugs/1797935

Title:
  Sending mail and saving drafts suddenly stopped working

Status in thunderbird package in Ubuntu:
  Invalid

Bug description:
  Since today I can neither send messages nor store drafts. Restarting
  thunderbird does not help. No error message is displayed. Receiving
  messages works fine.

  ProblemType: Bug
  DistroRelease: Ubuntu 18.04
  Package: thunderbird 1:52.9.1+build3-0ubuntu0.18.04.1
  ProcVersionSignature: Ubuntu 4.2.0-19.23~14.04.1-generic 4.2.6
  Uname: Linux 4.2.0-19-generic x86_64
  AddonCompatCheckDisabled: False
  ApportVersion: 2.20.9-0ubuntu7.4
  Architecture: amd64
  AudioDevicesInUse:
   USER PID ACCESS COMMAND
   /dev/snd/controlC0:  pia        2804 F.... pulseaudio
   /dev/snd/controlC1:  pia        2804 F.... pulseaudio
  BuildID: 20180710084133
  Channel: Unavailable
  Date: Mon Oct 15 18:42:48 2018
  Extensions: extensions.sqlite corrupt or missing
  ForcedLayersAccel: False
  IncompatibleExtensions: Unavailable (corrupt or non-existant 
compatibility.ini or extensions.sqlite)
  InstallationDate: Installed on 2015-11-05 (1075 days ago)
  InstallationMedia: Ubuntu 14.04.3 LTS "Trusty Tahr" - Beta amd64 (20150805)
  IpRoute:
   default via 10.75.15.254 dev eth0 proto dhcp metric 100 
   10.75.0.0/20 dev eth0 proto kernel scope link src 10.75.0.25 metric 100 
   169.254.0.0/16 dev eth0 scope link metric 1000
  Locales: extensions.sqlite corrupt or missing
  MostRecentCrashID: bp-d23c5e7f-dfca-4ae1-9026-2e6b30180601
  Plugins: Shockwave Flash - /usr/lib/gnash/libgnashplugin.so 
(browser-plugin-gnash)
  PrefErrors: 'utf-8' codec can't decode byte 0xe4 in position 928: invalid 
continuation byte
  Prefs:
   javascript.options.showInConsole: true 
([Profile]/extensions/[email protected]/defaults/preferences/debug.js)
   javascript.options.strict: true 
([Profile]/extensions/[email protected]/defaults/preferences/debug.js)
  Profiles: Profile0 (Default) - LastVersion=52.9.1/20180710084133
  PulseList:
   Error: command ['pacmd', 'list'] failed with exit code 1: Home directory not 
accessible: Permission denied
   No PulseAudio daemon running, or not running as session daemon.
  RelatedPackageVersions: browser-plugin-gnash 0.8.11~git20160608-1.4
  RunningIncompatibleAddons: False
  SourcePackage: thunderbird
  Themes: extensions.sqlite corrupt or missing
  UpgradeStatus: Upgraded to bionic on 2018-05-24 (144 days ago)
  dmi.bios.date: 04/15/2014
  dmi.bios.vendor: American Megatrends Inc.
  dmi.bios.version: 4.6.5
  dmi.board.asset.tag: Tag 12345
  dmi.board.name: W230SS
  dmi.board.vendor: Notebook
  dmi.board.version: Not Applicable
  dmi.chassis.asset.tag: No Asset Tag
  dmi.chassis.type: 9
  dmi.chassis.vendor: Notebook
  dmi.chassis.version: N/A
  dmi.modalias: 
dmi:bvnAmericanMegatrendsInc.:bvr4.6.5:bd04/15/2014:svnNotebook:pnW230SS:pvrNotApplicable:rvnNotebook:rnW230SS:rvrNotApplicable:cvnNotebook:ct9:cvrN/A:
  dmi.product.name: W230SS
  dmi.product.version: Not Applicable
  dmi.sys.vendor: Notebook

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