I have the same issue since a little while under Fedora 40, and I'm not
the only one according to https://support.mozilla.org/en-
US/questions/1463519 but I don't seem to have the environment variables
reported here (I created a dummy script which saves its environment
variables in a file and set it as mailto handler in Firefox:

```
MOZ_GRE_CONF=/etc/gre.d/gre64.conf
MOZ_CRASHREPORTER_STRINGS_OVERRIDE=/usr/lib64/firefox/browser/crashreporter-override.ini
MOZ_CRASHREPORTER_DATA_DIRECTORY=/home/ericl/.mozilla/firefox/Crash Reports
MOZILLA_FIVE_HOME=/usr/lib64/firefox
MOZ_DBUS_APP_NAME=firefox
MOZ_LAUNCHED_CHILD=
MOZ_CRASHREPORTER_PING_DIRECTORY=/home/ericl/.mozilla/firefox/Pending Pings
MOZ_ALLOW_DOWNGRADE=1
MOZ_APP_SILENT_START=
MOZ_CRASHREPORTER_RESTART_ARG_1=
MOZ_GMP_PATH=/usr/lib64/mozilla/plugins/gmp-gmpopenh264/system-installed
MOZ_ASSUME_USER_NS=1
MOZ_APP_LAUNCHER=/usr/bin/firefox
MOZ_CRASHREPORTER_EVENTS_DIRECTORY=/home/ericl/.mozilla/firefox/rkvgmvr5.default-release/crashes/events
MOZ_USE_XINPUT2=1
MOZ_APP_REMOTINGNAME=org.mozilla.firefox
MOZ_PLUGIN_PATH=/usr/lib64/mozilla/plugins:/usr/lib64/firefox/plugins
```

If I create a wrapper script and unset alll these variables, then
thunderbird starts properly, something like:

```
#!/usr/bin/bash

for var in $(env | sed -n -e '/^MOZ/ s/=.*//p')
do
        unset "${var}"
done
exec thunderbird "$@"
```

-- 
You received this bug notification because you are a member of Desktop
Packages, which is subscribed to thunderbird in Ubuntu.
https://bugs.launchpad.net/bugs/711305

Title:
  Thunderbird is already running, but is not responding. To open a new
  window, you must first close the existing Thunderbird process, or
  restart your system. Error received when clicking a mailto link in
  firefox.

Status in Mozilla Thunderbird:
  Confirmed
Status in thunderbird package in Ubuntu:
  Triaged

Bug description:
  Binary package hint: thunderbird

  This thunderbird error is given when clicking a mailto link. Instead
  of using the thunderbird that's already open it tries to open a new
  instance. Preferred Applications has Thunderbird select, but I have
  also tried Custom command "thunderbird %s". This has been tested on
  10.04 and 10.10. Both result in this error if thunderbird is already
  running.

  Thunderbird is already running, but is not responding. To open a new
  window, you must first close the existing Thunderbird process, or
  restart your system.

  ProblemType: Bug
  DistroRelease: Ubuntu 10.10
  Package: thunderbird 3.1.7+build3+nobinonly-0ubuntu0.10.10.1
  ProcVersionSignature: Ubuntu 2.6.35-25.44-generic 2.6.35.10
  Uname: Linux 2.6.35-25-generic i686
  Architecture: i386
  Date: Tue Feb  1 10:19:09 2011
  InstallationMedia: Ubuntu 10.10 "Maverick Meerkat" - Release i386 (20101007)
  ProcEnviron:
   LANG=en_CA.utf8
   SHELL=/bin/bash
  SourcePackage: thunderbird

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