Just subscribed to post that I found an issue using the Flex 3.2 installer on a new Mac laptop with OS 10.13. I filed a Jira ticket[1]. Just like iOS, for Mac 10.13 it seems like if your application makes HTTP calls, you need to include in the Info.plist the NSAppTransportSecurity/NSAllowsArbitraryLoads keys.
[1] https://issues.apache.org/jira/browse/FLEX-35365 -- Sent from: http://apache-flex-development.2333347.n4.nabble.com/