Want to bring into discussion people that are not on Google+. Samuel recently has posted there some simple experiments with bioinformatics and bad performance of Phobos-based snippet has surprised me.

I did explore issue a bit and reported results in a blog post (snippets are really small and simple) : http://dicebot.blogspot.com/2013/05/short-performance-tuning-story.html

One open question remains though - can D/Phobos do better here? Can some changes be done to Phobos functions in question to improve performance or creating bioinformatics-specialized library is only practical solution?

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