#918: Treatment and prevention of Legionella Infection ###
-----------------------------------+----------------------------------------
Reporter: rinocata1983 | Type: task
Status: new | Priority: major
Milestone: | Component: Architecture
Severity: New Ticket | Keywords:
Who will test this: And |
-----------------------------------+----------------------------------------
The mortality of community-acquired Legionnaires' disease ranges from 16
to 30 percent if untreated or treated with inactive antibiotics; the
mortality for nosocomial Legionnaires' disease can approach 50 percent
given the underlying condition of the individual. With the development of
improved diagnostic methods leading to livlier and earlier diagnosis
therapies, mortality has been reduced to less than 10 % in patients with
community-acquired legionellosis.
The treatment of Legionella disease is likely to be [http://www.yan588.com
/treating-legionnairesa-disease/ human resources manager] examined here.
The pathogenesis, epidemiology, clinical manifestations, and diagnosis of
this entity are discussed separately.
Vulnerability ASSESSMENT
In since methods haven't been standardized vitro susceptibility email
address details are not readily interpretable for Legionella. Main-stream
in vitro susceptibility techniques in broth and agar have proven
unreliable. For example, agar is extracted by the charcoal in buffered
charcoal yeast used for Legionella solitude binds antibiotics, and thus,
activity of those antibiotics against the organism is incorrectly
decreased. Also, several commercially available antibiotics, which have
exceptional in vitro activity against Legionella by traditional screening
(eg, beta-lactam agents and aminoglycosides), have shown to be relatively
ineffective in patients with Legionnaires' disease.
The intracellular site of the virus is applicable to the efficacy of the
antibiotic. Antibiotics capable of reaching intracellular concentrations
higher than the minimum inhibitory concentration (MIC) are far more
effective clinically than medicines with poor intracellular penetration.
Medicines with intracellular penetration are the macrolides, quinolones,
tetracyclines, and rifampin.
The empiric discovering that tetracycline and erythromycin seemed to be
more effective than beta-lactam brokers and aminoglycosides in early
outbreaks of Legionnaires' disease was in line with in vitro results in
intracellular and animal models of Legionnaires' disease. Determination of
the susceptibility of Legionella spp to antimicrobial agents is currently
based on animal models and such intracellular of Legionella infection
--
Ticket URL: <http://plumi.org/ticket/918>
Plumi <http://plumi.org/>
Plumi - FOSS Video Sharing Platform
_______________________________________________
Discuss mailing list
[email protected]
http://lists.plumi.org/listinfo/discuss
