#918: spam
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Reporter: | Owner:
Type: task | Status: closed
Priority: major | Milestone:
Component: Architecture | Severity: New Ticket
Resolution: invalid | Keywords:
Who will test this: And |
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Changes (by cpsaltis):
* status: new => closed
* reporter: rinocata1983 =>
* resolution: => invalid
Old description:
> The mortality of community-acquired Legionnaires' disease ranges from 16
> to 30 percent if untreated or treated with inactive antibiotics; the
> mortality for nosocomial Legionnaires' disease can approach 50 percent
> given the underlying condition of the individual. With the development of
> improved diagnostic methods leading to livlier and earlier diagnosis
> therapies, mortality has been reduced to less than 10 % in patients with
> community-acquired legionellosis.
>
> The treatment of Legionella disease is likely to be
> [http://www.yan588.com/treating-legionnairesa-disease/ human resources
> manager] examined here. The pathogenesis, epidemiology, clinical
> manifestations, and diagnosis of this entity are discussed separately.
>
> Vulnerability ASSESSMENT
>
> In since methods haven't been standardized vitro susceptibility email
> address details are not readily interpretable for Legionella. Main-stream
> in vitro susceptibility techniques in broth and agar have proven
> unreliable. For example, agar is extracted by the charcoal in buffered
> charcoal yeast used for Legionella solitude binds antibiotics, and thus,
> activity of those antibiotics against the organism is incorrectly
> decreased. Also, several commercially available antibiotics, which have
> exceptional in vitro activity against Legionella by traditional screening
> (eg, beta-lactam agents and aminoglycosides), have shown to be relatively
> ineffective in patients with Legionnaires' disease.
>
> The intracellular site of the virus is applicable to the efficacy of the
> antibiotic. Antibiotics capable of reaching intracellular concentrations
> higher than the minimum inhibitory concentration (MIC) are far more
> effective clinically than medicines with poor intracellular penetration.
> Medicines with intracellular penetration are the macrolides, quinolones,
> tetracyclines, and rifampin.
>
> The empiric discovering that tetracycline and erythromycin seemed to be
> more effective than beta-lactam brokers and aminoglycosides in early
> outbreaks of Legionnaires' disease was in line with in vitro results in
> intracellular and animal models of Legionnaires' disease. Determination
> of the susceptibility of Legionella spp to antimicrobial agents is
> currently based on animal models and such intracellular of Legionella
> infection
New description:
spam
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