There are lots of options. One that I have had success with is snakemake.

https://bitbucket.org/johanneskoester/snakemake/wiki/Home
https://pypi.python.org/pypi/snakemake/3.1
http://bioinformatics.oxfordjournals.org/content/28/19/2520.full

You set up Makefile-like rules (except that they are easier to read),
and then you can either execute the jobs serially or have them batch
submitted.

John

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