JEFFERSON RESEARCHERS FIND DRUG MAY GIVE SOME CARDIAC PROTECTION 24 
HOURS AFTER HEART ATTACK


A drug has been shown to provide some protection to the heart from 
injury even if given as much as 24 hours after a heart attack, 
Jefferson Medical College researchers report.

Walter Koch, Ph.D., director of the Center for Translational Medicine 
in the Department of Medicine at Jefferson Medical College of Thomas 
Jefferson University in Philadelphia, and his co-workers knew that 
the drug Darbepoietin alpha would protect the ischemic heart. 
Darbepoietin is a long-acting cousin of erythropoietin (EPO), which 
has been shown to offer some protection to the heart from injury from 
ischemia, or a lack of oxygen. In previous studies, Dr. Koch had 
given EPO at the time of simulated heart attack in an another animal 
model, and found it protected the animals.

But in further studies, Dr. Koch gave Darbepoietin to animals at the 
time of ischemia and heart attack,
one to two hours after, and 24 hours later. In each case, the 
scientists saw that the drug offered significant protection to heart 
tissue, and even helped improve cardiac function. 

Dr. Koch believes the results "may be quickly translated into 
clinical trials." He and his team present their findings on November 
16, 2005 at the American Heart Association's Scientific Sessions 2005 
in Dallas.

source: http://www.brightsurf.com/news/headlines/view.article.php?
ArticleID=21880 

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