Mail Issues - FreeBSD

Hello, my apologies if this may be the wrong forum but hoping that maybe 
someone might be able to provide some insight.

Have a very sporadic and strange issue with our mail servers running Dovecot on 
FreeBSD.  There are three servers hosting Dovecot with FreeBSD as the 
underlying operating system.  All three connect to a NAS server, again running 
FreeBSD and ZFS.

When the specific issue occurs, clients connecting to check mail via POP3 or 
IMAP experience long delays and timeouts.  To the point where POP3 Logins fail 
due to the timeouts.  The issue is further compounded by clients increasing the 
number of attempts to check mail.

Part of the frustration in attempting to diagnose the issue is not knowing the 
root cause or symptom that initates the issue.

Wondering if anyone has experienced anything similar, or suggestions on ways to 
help identify the root cause

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