depending on the size of mailboxes you may choose multiple big groups instead 
of one single.

may stavan correct me but my expierence is.
if you have many multiple languages in the email traffic and and many different 
busninesses (like medical, industrial, sales, esales, private mails and so on)
you may not able to have a good and accurate only global training.

so with one global group for a smal set.
and multiple big groups might do the trick

ok if its only 2000+ mailboxes it should not be nessesary.
i googled it, your company self say they host 2.5 million domains. i expected 
much more mailboxes :-)
i mean i have have 500k or a million mailboxes everything is much different 
(very different)
2.5 k instead should be easy :-) i think in that case one globalgroup will do 
fine, you can even do a personal additional training for your users
and one central webinterface on one box. should run fine 




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