I run 3 monitors at work. I have the AGP Nvidia card that came in a Gateway P4 as the primary monitor in the middle, and a Matrox Dual port PCI card for monitors 2 and 3 on the left and right respectively. I generally have DXBase (2006) running on the left monitor, what I'm actively working on the main monitor and other software monitoring servers at work on the right monitor.
The first thing I noticed is when you click on the speaker Icon to enable/disable the voice announce icons, it will not toggle when on the left monitor. If I drag the DXBase window to the center monitor, it toggles on and off as expected. So, whenever I want to change the state of the voice spot announcements, I have gotten used to doing that. I reported it to Jack long ago and he assured me it was something with my configuration or drivers. I was running the most recent drivers on both video cards as of a few months ago, but I haven't checked recently for new ones. Since this PC and the associated cards are about 3 years old, I'd suspect there probably aren't any significant driver updates on that old of hardware. I have also noticed that when you have DXBase maximized on the left monitor, some information from long lines in the cluster window tend to extend over to the center monitor from time to time. I have also seen some of the scrolling issues mentioned on both my home PC and my work PC. Dave Chasey - N9FN

