I am facing the same problem with MySQL. I have changed the datasources 
appropriately as mentioned in the Nuxeo-book, but still the same issue.

Caused by: org.nuxeo.ecm.core.api.WrappedException: Exception: 
javax.jcr.RepositoryException. message: The repository home 
D:\AP_DMS\NuxeoServer\server\default\data\NXRuntime\repos\nuxeo appears to be 
in use since the file named .lock is locked by another process.
        at 
org.apache.jackrabbit.core.util.RepositoryLock.acquire(RepositoryLock.java:129)
        at 
org.apache.jackrabbit.core.RepositoryImpl.<init>(RepositoryImpl.java:229)
        at 
org.nuxeo.ecm.core.repository.jcr.JCRRepository.<init>(JCRRepository.java:65)
        at 
org.nuxeo.ecm.core.repository.jcr.JCRRepository.create(JCRRepository.java:83)
        at 
org.nuxeo.ecm.core.repository.jcr.JCRRepositoryFactory.createRepository(JCRRepositoryFactory.java:56)
        at 
org.nuxeo.ecm.core.repository.RepositoryDescriptor.create(RepositoryDescriptor.java:156)
        at 
org.nuxeo.ecm.core.repository.RepositoryManager$Ref.get(RepositoryManager.java:196)
        at 
org.nuxeo.ecm.core.repository.RepositoryManager.getRepository(RepositoryManager.java:78)
        at 
org.nuxeo.ecm.core.api.local.LocalSession.createSession(LocalSession.java:69)
        ... 186 more
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