*Postdoctoral Fellowship* *Molecular Evolution*
*Evolution of detoxification enzymes*: The Dearing lab at the University of Utah invites applications for a postdoctoral fellow to participate in a study on the evolution of detoxification enzymes in mammalian herbivores. This collaborative project will investigate the detoxification enzymes in the cytochrome P450 subfamily 2B (CYP2B) and their role in the biotransformation of plant secondary compounds, particularly terpenes. Changes in the amino acid sequence, structure and copy number of CYP2B enzymes may be key to an herbivore’s ability specialize on a terpene-rich diet. Future work consists of sequencing, characterizing and comparing the amino acid sequences of CYP2B enzymes of specialist and generalist woodrats (*Neotoma spp.*) and possibly other mammalian terpene feeders. We are currently sequencing the genome of *Neotoma lepida* with assembly expected Fall 2014. Characterization of protein function will be achieved using heterologous expression systems in collaboration with Dr. James Halpert, UConn, and there are opportunities for interactions with his research group. For more information on previous related research, see: http://biologylabs.utah.edu/dearing/Lab/pdf/2012_journal_pone.pdf http://biologylabs.utah.edu/dearing/Lab/pdf/2009_expression_biotrans_magnanou.pdf The ideal candidate should have a background in addressing questions of molecular evolution, molecular ecology or plant-animal interactions. Experience accessing and evaluating genomic data, using molecular techniques are desirable. The candidate should have at least one first authored publication in press. The Dearing lab provides a strong training and career development environment for candidates interested in academic positions. Teaching experience (Mammalogy) is a possibility for interested candidates, and animal collection fieldwork is possible. *Applications will be reviewed through Sept 26, 2014. *Expected start date is October 31st. Funding is anticipated for 2 years. Please send a C.V., statement of research interests that includes career goals (1-2 pgs), pdfs of papers, and contact information (emails and phone numbers) for at least 3 professional references to Dr. Denise Dearing, care of Jael Malenke, [email protected] <[email protected]>; please put “Postdoctoral Applicant CYP2B” in the Subject Line.
