In article <5PX_4.402$[EMAIL PROTECTED]>,
"Isabelle Gaboury" <[EMAIL PROTECTED]> wrote:
> Hi,
>
> I'm looking for articles and books (or authors) which can help me to
> compute the sample size (and related power) in case of a case-control
study
> of a rare disease.
>
> By the way, is there a newsgroup for biostatistic topics???
>
> Thanks for your help,
> Isabelle
>
I will answer the simple question first: I am not aware of any newsgroup
specific to biostatistics.
Assuming you outcome is also categorical (like disease status yes/no,
or present/absent), I would start with Fleiss's book "Statistical
Methods for Rates and Proportions" where he has introductory sample size
discussions for a variety of situations.
In a rare disease situation, the number of cases will be limited and
hence it might be more practical to calculate the minimum detectable
difference, i.e. start with a feasible sample size and a reasonable
power (80-90%) and calculate the minimum difference you can detect with
this sample.
Mithat
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