San wrote:
> 
> Would there be some cases which the p-value are so difficult to find
> that it's nearly impossible? 

I'm tempted to say "not under a randomization model" but, yes, there
are many problems for which P values are not readily available. 
Perhaps P values are unavailable for *most* problems--it's just that
we're so good at figuring out new uses for the cases we can solve! 
A good example of a simple situation for which exact P values are
unavailable is the Behrens-Fisher problem (testing the equality of
normal means from normal populations with unequal variances).  Some
might say we have approximate solutions that are good enough.

> Is this a kind of limitation to the
> hypothesis testing using p-value? 

Yes.  Stepwise procedures (regression, in particular) are good
examples.

> Is there any substitute for the
> p-value?

Many.  You could start with likelihood procedures, Bayes methods,
and decision theory.


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