Could any help on how to repeatedly generated random samples for a 2x3
or 2x4 cross over design for individual and population bioequivalence
specifying the the following parameters:

means: both test and reference formulation:
within subject variance for both test and reference formulation:
between subject variance for both test and reference formulations:
the subject by formulation interaction:

The observations generated should be correlated.

And how to evaluate the size and power of any of the statistical
procedures for IBE and PBE.

Regards,
Bon
.
.
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