On 7 Aug 2003 05:18:17 -0700, [EMAIL PROTECTED] (Ren�) wrote: > Performing scientific investigations of poison exposure in the lab, we > have an experimental design with a set of reference and a treated > samples (say A-samples and B-samples). We ad some chemical and measure > a response at several time intervals after the exposure � and at each > point in time A and B measurements are made in triplicate (response > could be concentration of a metabolite, number of living cells, a > color or the like). We then make an XY (time/response) plot and fit a > curve (could be an exponential decay for example). As we measure in > triplicate at each time there is variation on each measurement point > on both A and B values. Though, in spite of fluctuations and > decreasing response for both the A and the B curve it seems that the A > response curve is higher than the B curve "most of the time"� How do > we make a statistical test of this? It should takes into account the > decay (response levels are not constant over time) and preferably the > variation in the triplets observations?
Does A consist of 3 critters which are tested several times, and B likewise? - Then you have a t-test of 3 versus 3, on whatever-parameter-it-is that models the height of the curve. (There would be other ways, but that one is my first choice.) Or is this the model where 3 rats (say) have to be 'sacrificed' at each time point in order to get those replicated values? - Then you might have the 2-way ANOVA, time by group, where you test the group-effect against the TxG interaction, and test the interaction against the within (that is, residual). > > In a reply to a similar question (posted by Don Taylor to newsgroup > sci.stat.math 1997/05/26 ) it was suggested that in AUTOBOX the > problem could be treated as a 'POOLED CROSS-SECTIONAL TIME SERIES' � > however, it was not clear how to treat this problem in general (we do > not have AUTOBOX). Does anyone have a hint or reference how to solve > this problem? -- Rich Ulrich, [EMAIL PROTECTED] http://www.pitt.edu/~wpilib/index.html "Taxes are the price we pay for civilization." Justice Holmes. . . ================================================================= Instructions for joining and leaving this list, remarks about the problem of INAPPROPRIATE MESSAGES, and archives are available at: . http://jse.stat.ncsu.edu/ . =================================================================
