Dear newsgroup, i want to design a hypothetical clinical trial with two main questions and a double randomization design, which means that each patient will be randomized two times for treatment and there is no interaction between treatment A and B. (so no 2x2 factorial design) As i have to main questions to be tested on the same data i must adjust my alpha because of multiplicity issues. My question is: The sample size of the trial will be determined by the overall alpha and beta, or by the individual alpha and beta (e.g. the two tests (main questions))?????
Greetings Christoph Int-Veen . . ================================================================= Instructions for joining and leaving this list, remarks about the problem of INAPPROPRIATE MESSAGES, and archives are available at: . http://jse.stat.ncsu.edu/ . =================================================================
