Hi! I would like to make some suggestions to enhance the utility of backtranseq: - At present backtranseq uses the most preferred codon exclusively for a given amino acid. It would be nice if it could use all synonymous codons with probabilities defined by their usage. For example, codon usage for Ala in humans is 0.10, 0.22, 0.28 and 0.40 for GCG, GCA, GCT and GCC respectively. So, all 4 codons could be used for Ala, with GCC being used most often and GCG the least number of times. - Allow for uniform usage of all synonymous codons, for example to carry out an in-silico experiment by eliminating codon preference. - Also, I find if I give backtranseq a file in multi-fasta format, it translates only the first sequence. Thanks. Shrish Dr. Shrish Tiwari E503, Centre for Cellular and Molecular Biology Uppal Road, Hyderabad - 500 007, INDIA Phone: 91-40-27192777 Alternate email: [EMAIL PROTECTED]
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