I use /etc/procmailrc to point to a series of includes in /etc/procmail 
that filter junkmail and viral/worm activity. It sanitizes headers, alters
suspect attachments so they require a bit of thought by the user to open,
rather than auto-opening via outlook.
This set of filters operates on all email that comes into my mailserver.
This server hosts POP/IMAP/SMTP  for 100+ domains.

The following is what i use:
ftp://ftp.rubyriver.com/pub/jhardin/antispam/procmail-security.html

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