On Tue, 18 Sep 2001, larry a price wrote:
> This provides many benefits that would be completely absent in a more
> normal setting, the primary one being the exercise,
Exercise causes reactive oxygen species (ROS) to be created, potentially
shortening lifespan:
J Physiol Biochem 2001 Mar;57(1):9-14
Physical exercise intensity can be related to plasma glutathione levels.
Gambelunghe C, Rossi R, Micheletti A, Mariucci G, Rufini S
Department of Clinical and Experimental Medicine, University of Perugia,
Italy. [EMAIL PROTECTED]
[Medline record in process]
The aim of the present study was to examine the effect of different kinds
of physical exercise on plasma glutathione levels. Male Wistar rats were
randomly divided into four groups: In walking group (W; n=6), rats were
trained to walk 0.8 m/min for 45 min; slow running group (SR; n=6) were
trained to run 4 m/min for 45 min; fast running group (FR; n=6) ran 8
m/min for 60 min and control rats (C; n=6) remained in their home
cages. All animals were sacrificed after exercise and the levels of
reduced glutathione (GSH) in plasma samples determined by high performance
liquid chromatography (HPLC) with a fluorescent detector. Compared to
controls, exercise did not change GSH plasma levels of the W group. A
tendency to decrease blood GSH was observed in plasma samples of the SR
group and in the FR group, physical exercise resulted in a dramatic
decrease in GSH plasma levels. These data suggest that during light
physical exercise there is a low production of reactive oxygen species
(ROS) with a low request for antioxidant defence such as oxidation of
GSH. The dramatic decrease observed in GSH levels in FR rats would
indicate the presence of oxidative stress able to modify blood antioxidant
profiles. Our results suggest that GSH plays a central antioxidant role in
blood during intensive physical exercise and that its modifications are
closely related to exercise intensity.
PMID: 11519887, UI: 21410675
-Chris
