I found that the lovastatin anticholesterol I had been taken interacts with 


Posted at 07:00 AM ET, 11/27/2012 
More medications now interact with grapefruit; results sometimes dire 

By Jennifer LaRue Huget The number of medications that interact with 
grapefruit, with 
potentially serious results, is on the rise, new research finds. 
In a study published Monday in the Canadian Medical Association Journal, the 
team of 
Canadian researchers who 20 years ago discovered that grapefruit interferes 
with the body
metabolism of certain drugs reports that the number of such drugs on the market 
increased substantially in recent years. 

They found that between 2008 and 2012, about six new medications whose 
with grapefruit can cause serious damage came to market each year, bringing the 
from 17 to 43. (Altogether, more than 85 drugs that might interact with 
grapefruit exist, 
but some such interactions aren? likely to cause serious adverse effects.) 
Chemicals in grapefruit called furanocoumarins change the way these medications 
metabolized in the gastrointestinal tract, dramatically increasing 
concentrations of the drug 
in the bloodstream. Those chemicals are also present in other citrus fruits 
such as Seville oranges 
the kind often used to make marmalade and limes and pomelos, the study notes, 
but not in oranges. 
The drugs in question have three common traits: They're all taken orally, they 
all have limited bioavailability 
(meaning only small percentages of the active drug make it into the bloodstream 
under normal circumstances) 
and they all interact in the GI tract with an enzyme called CYP3A4. That 
information is available on drug 
package inserts, the study notes, but many people, including physicians, may 
not be aware of its importance. 
The list of such drugs includes commonly used cholesterol-lowering statins such 
as Zocor and Lipitor and 
blood-pressure medications such as Nifediac and Afeditab, the study notes. 
Those high concentrations of drugs in the body can be toxic to the kidneys and 
can also lead to GI-tract bleeding, 
respiratory failure, bone-marrow suppression (among people with comprised 
immune systems)  -
- and even sudden death. 
These interactions can take place many hours after grapefruit (or grapefruit 
juice) is consumed,
 and even just a single grapefruit or glass of grapefruit juice a day can spell 
trouble if you?e 
taking one of these drugs.. 

Those of us older than 45 are at increased risk, in part because, the study 
notes, we 
buy more grapefruit than younger people do and also have more prescription 
drugs in our lives. 
Older people are more susceptible to the ill effects of high concentrations of 
drugs in their system,
too, the study says. 

This all means that it's a good idea to ask your physician or pharmacist about 
prescription drugs you take and whether they?e likely to be affected by 
grapefruit consumption. 

By Jennifer LaRue Huget  |  07:00 AM ET, 11/27/2012  

[Roger Clough], [rclo...@verizon.net] 
"Forever is a long time, especially near the end." -Woody Allen

You received this message because you are subscribed to the Google Groups 
"Everything List" group.
To post to this group, send email to everything-list@googlegroups.com.
To unsubscribe from this group, send email to 
For more options, visit this group at 

Reply via email to