Pretty cool piece of news.. kind of pushes the envelope of our grasp of living systems. It adds yet one more layer (upon layers) to the decisional machinery of cellular scale life. It is a pure protein executed process, occurring within a ribosome… no RNA/DNA instructions involved!
>From Ray Kurzweil’s newsletter ><http://www.kurzweilai.net/protein-partially-assembles-another-protein-without-genetic-instructions?utm_source=KurzweilAI+Daily+Newsletter&utm_campaign=954bfc4219-UA-946742-1&utm_medium=email&utm_term=0_6de721fb33-954bfc4219-281942553> > : Defying textbook science, amino acids (the building blocks of a protein) can be assembled by another protein and without genetic instructions, according to a study published today (Jan. 2) in Science. It happens just before an incomplete protein is recycled due to an assembly failure: a protein called Rqc2 prompts ribosomes (which assemble proteins) to add just two amino acids (of 20 total) — alanine and threonine — over and over, and in any order, playing a role similar to that of messenger RNA. The apparently random sequence of amino acids probably doesn’t work normally, but may serve specific purposes, the scientists suggest. The code could signal that the partial protein must be destroyed, or it could be part of a test to see whether the ribosome is working properly. Evidence suggests that either or both of these processes could be faulty in neurodegenerative diseases such as Alzheimer’s, Amyotrophic lateral sclerosis (ALS), or Huntington’s. The senior authors are Peter Shen, Ph.D., a postdoctoral fellow in biochemistry at the University of Utah; Adam Frost, M.D., Ph.D., assistant professor at University of California, San Francisco; Jonathan Weissman, Ph.D., a Howard Hughes Medical Institute investigator at UCSF; and Onn Brandman, Ph.D., at Stanford University. The research was supported by grants from the Searle Scholars program, the National Institutes of Health, the Howard Hughes Medical Institute, Stanford University, and the University of Utah. -- You received this message because you are subscribed to the Google Groups "Everything List" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. To post to this group, send email to [email protected]. Visit this group at http://groups.google.com/group/everything-list. For more options, visit https://groups.google.com/d/optout.
