> On 22 Jan 2020, at 01:03, John Clark <[email protected]> wrote: > > The journal Nature Immunology published an article yesterday that I think > could be pretty important in the war on cancer: > > CRISPR–Cas9 screening reveals ubiquitous T-cell cancer targeting via the > monomorphic MR1 protein > <https://www.nature.com/articles/s41590-019-0578-8.epdf?referrer_access_token=HDEpkmPOLIXidFQ7vTmyyNRgN0jAjWel9jnR3ZoTv0NjOoBZR7tEtwlsa1xeSU1tSn9OqKp9tJ7vTk8p7vCmAU4NZd5dS3BIALSEUtLFcpomMuKDUbEnW8GutXD_HuOev_ekvAEfzAa2kC03oyp2SuhBvB2N5K9feGAqhcKqIKgZC2OWk5VF1AgHIU4VXmKYtA08E37GZ-mC1LVqbRLRew%3D%3D&tracking_referrer=www.bbc.com> > > It's been Known for some time that T-cells can be extracted from a cancer > patient and genetically modified with CRISPR to produce a receptor for the > patient's cancer and therefore label it as malignant so the immune system can > attack it. This has produced some very good results for some cancers like > leukemia but unfortunately the treatment must be personalized for each > patient and is far less effective in dealing with large solid cancers. But in > this new discovery they found a protein called MR1 that does not change from > person to person and exists on the surface of many different types of > cancers. When they used CRISPR to make T-cells to produce a receptor for this > MR1 protein the results have been encouraging. > > So far they've only tried it with mice and with human cells in vitro, but at > least in those limited circumstances it has been shown to kill lung, skin, > blood, colon, breast, bone, prostate, ovarian, kidney, and cervical cancer > cells but seems to have no effect at all on non-cancerous normal cells. And > one size fits all, no personalization is needed. It remains to be seen if > this works as well in clinical trials, sometimes they don't, but one can hope. > > Scientist Finds New Blood Cell That Kills Cancer While Ignoring Healthy Cells > <https://www.youtube.com/watch?v=esV98_-IIMc> >
My favorite paper on Cancer is the famous Spanish paper of 2000: https://www.jci.org/articles/view/37948 It is a (re)discovery, in Spain, that THC cures some cancer, and indeed in way killing only cancerous cells without harming healthy cells. The original discovery was made in 1974 by Americans, but has been hidden to the general public, and I have never found a copy of the publication. This explained a little bit here: http://www.mapinc.org/newstcl/v01/n572/a11.html When I read this in the book on Hemp by Jack Herer, I thought that he was exaggerating or just doing pro-cannabis propaganda, but everything Jack Herer said in his book has been confirmed, including the “conspiracy” against letting people know this. After all the American were paid to prove that cannabis provoke cancer, and the boss was not happy with the result! Note also that since then, many other cannabinoids having a negative impact on cancer has been found. The CBD has also anti-cancerous properties, and according to which kind of cancer needs to be treated, the relative concentration of different cannabinoids plays an important rôle. Another interesting paper is https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387667/ Bruno > John K Clark > > -- > You received this message because you are subscribed to the Google Groups > "Everything List" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected] > <mailto:[email protected]>. > To view this discussion on the web visit > https://groups.google.com/d/msgid/everything-list/CAJPayv0o_HwbCKQBqA%3DQVPnYqULQe%3DywbCo9KfRJ5VCdwLU2Ew%40mail.gmail.com > > <https://groups.google.com/d/msgid/everything-list/CAJPayv0o_HwbCKQBqA%3DQVPnYqULQe%3DywbCo9KfRJ5VCdwLU2Ew%40mail.gmail.com?utm_medium=email&utm_source=footer>. -- You received this message because you are subscribed to the Google Groups "Everything List" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. To view this discussion on the web visit https://groups.google.com/d/msgid/everything-list/1BD60177-B97D-4B25-A6AD-E2E680D1D00D%40ulb.ac.be.
