When it comes to space colonization or a permanent presence in space we must 
have some clear positive economic feedback. It is of no use to build a base or 
colony on the moon, or even more outlandishly on Mars, if there is no return on 
investments. Maybe solar power satellites and then mining small near Earth 
asteroids are a start. Yet, so far no clear strategy exists. 

It is a matter of industry and economics and not science. We can do plenty of 
science in space without astronauts. In fact rather little science comes from 
putting people in space.

If we do have some trajectory into space it is possible genetic reengineering 
of Homo sapiens may become necessary. Brave New World may become reality.

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