Hi Paul, Thanks for you Good suggestions will apply the same in future, the 
thing which i was looking to remove the InStr statements which is checking 
multiply as you instructed combining the values first and adding it in 
dictionary object to remove duplicacy(Given Below) will not combine the 
result as like my output given in the attachment if you run my macro. Still 
thanks a lot.  

Sub Test()
Dim varData As Variant, varOut() As Variant
Dim i As Long, j As Long
Dim myDic As Object
Dim key As String, myStr As String

With Sheets("Sheet1")
    If myDic Is Nothing Then
        Set myDic = CreateObject("Scripting.Dictionary")
        varData = .Range("A1:D1085")
        For i = LBound(varData) To UBound(varData)
            key = varData(i, 1) & "," & varData(i, 2) & "," _
                & varData(i, 3) & "," & varData(i, 4)
            If Not myDic.Exists(key) Then
                myDic(key) = i
                ReDim Preserve varOut(j)
                varOut(j) = key
                j = j + 1
            End If
        Next
    End If
End With

With Sheets("Sheet2")
    For i = LBound(varOut) To UBound(varOut)
        .Cells(i + 1, 1).Resize(1, 4) = Split(varOut(i), ",")
    Next
End With
End Sub

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